Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Furthermore, the minor alleles of rs6983267 and rs1957636 were associated with worse CRC-specific and overall survival.
|
28567967 |
2017 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In particular, both homozygous TT and heterozygous CT genotypes of rs10505477, as well as the GG and TG genotypes of rs6983267, were associated with risk of colorectal cancer.Our study provides summary evidence that common variants in the 8q24 are associated with risk of colorectal cancer in this large-scale research synopsis and meta-analysis.
|
30170403 |
2018 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability.
|
23796952 |
2013 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In our previous work, we showed that the colorectal cancer (CRC) risk variant rs6983267 at 8q24 resides within a TCF4 binding site at the MYC-335 enhancer, with the risk allele G having a stronger binding capacity and Wnt responsiveness.
|
22429595 |
2012 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study highlighted the high CRC risk of people carrying rs6983267 G and rs11777210 C alleles, and provided possible biological mechanism of the interaction.
|
29267898 |
2018 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the 8q24.21-rs6983267 polymorphism is associated with CRC/CRA susceptibility, but these associations vary in different ethnic populations.
|
24375194 |
2014 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
To validate this finding, we genotyped rs6983267 in three additional CRC case-control series (4,361 affected individuals and 3,752 controls; 1,901 affected individuals and 1,079 controls; 1,072 affected individuals and 415 controls) and replicated the association, providing P = 1.27 x 10(-14) (allelic test) overall, with odds ratios (ORs) of 1.27 (95% confidence interval (c.i.): 1.16-1.39) and 1.47 (95% c.i.
|
17618284 |
2007 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The CRC SNPs accounted for 4.3% of the variation in multiple adenoma risk, with three SNPs (rs6983267, rs10795668, rs3802842) explaining 3.0% of the variation.
|
24801760 |
2015 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data suggested that the rs6983267 G > T polymorphism is a risk factor for CRC in Asians, Europeans, and Americans with European ancestry.
|
21722176 |
2011 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
|
18372905 |
2008 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Stratified analyses indicated that rs6983267 significantly increased the risk of colorectal cancer in Caucasians, prostate cancer in Caucasians and Asians, thyroid cancer in Caucasians and lung cancer in Asians.
|
28915683 |
2017 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In contrast, the recently identified CRC susceptibility allele rs6983267 mapping to 8q24 was significantly associated with disease risk (P=8.94 x 10(-8)).
|
18362937 |
2008 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
As expected, a significant association between the G allele of rs6983267 and CRC [OR, 1.22; 95% confidence interval (CI), 1.08-1.38; P = 0.0018] was found, confirming the previous observations.
|
18172290 |
2008 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The presence of the minor allele of rs6983267 at 8q24.21 worsened the prognosis of CRC through up-regulation of MYC transcription.
|
22976378 |
2013 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers.
|
27875818 |
2017 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found no significant differences between the association of rs6983267 and colorectal cancer and colorectal adenomas.
|
21455501 |
2011 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Results of this study suggests that the rs6983267 and rs10505477 polymorphisms alone may not be relevant to CRC risk, but their GG haplotype plays a notable role in age at diagnosis of CRC in the Iranian population.
|
24528058 |
2014 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found indications that aspirin interacted with rs6983267 close to MYC (encoding a transcription factor involved in cell cycle progression, apoptosis and cellular transformation) and NSAIDs interacted with rs3024505 and rs1800872 in or close to IL10 (encoding IL-10) in preventing CRC.
|
24889212 |
2014 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold.
|
21242260 |
2011 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs6983267 locus is also strongly associated with colorectal cancer.
|
18704501 |
2008 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, rs6983267 and rs7763881 are potential genetic markers of CRC predisposition and correlate with serum CCAT2 and HULC, two novel potential non-invasive diagnostic biomarkers for CRC.
|
29176650 |
2017 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs6983267 in region 3, previously implicated in CRC risk, trended toward association with disease in European Americans but not in African Americans.
|
19520795 |
2009 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 x 10(-6)) and that the apportionment of risk among the variants differs significantly between the two cancers.
|
17618282 |
2007 |
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Meta-analysis showed association between SNPs rs6983267, rs11694911 and rs2302615 with CRC risk reduction (All P<0.05).
|
29425227 |
2018 |