|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs738409 PNPLA3 genotype influences steatosis development in CHC and is independently associated with cirrhosis and other steatosis-related clinical outcomes, such as lack of response to antiviral treatment and possibly HCC.
|
21319195 |
2011 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
At multivariate analysis, the PNPLA3 rs738409 polymorphism was confirmed to be an independent predictor of HCC occurrence (odds ratio 1.76, 95% confidence interval 1.06-2.92, P<0.05).
|
21745286 |
2011 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence.
|
21745286 |
2011 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we studied whether the PNPLA3 rs738409 polymorphism also affects predisposition to hepatocellular carcinoma (HCC).
|
22087248 |
2011 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study is the first prospective report showing the association of the PNPLA3 I148M genetic variant and hepatocellular carcinoma in severely obese individuals.
|
22704398 |
2012 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was conducted to determine whether PNPLA3 rs738409 SNPs affect development and prognosis of hepatocellular carcinoma (HCC) in patients with various liver diseases.
|
22869157 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study provides key data that affirm the influence of the rs738409 (GG) genotype on the occurrence of HCC in patients with alcoholic cirrhosis.
|
23069476 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Next, we will analyze the evidences for the association between PNPLA3 I148M variant and HCC.
|
23333103 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 genetic variation (rs738409: C>G) may determine individual susceptibility to HCC development and poor prognosis.
|
23776098 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, these results suggest that rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent and provide a strong argument for performing further mechanistic studies to better understand the role of PNPLA3 in HCC development.
|
24114809 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 I148M polymorphism, clinical presentation, and survival in patients with hepatocellular carcinoma.
|
24155878 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as well as its pathobiological sequelae fibrosis, cirrhosis, and hepatocellular cancer.
|
24222094 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variation at rs738409 was not associated with significant changes in resolution rate of hepatitis C. By contrast, M/M genotype, present at higher frequencies (22.8%) in HCC patients than in patients with chronic hepatitis C (8.5%, P = 0.004) or control individuals (9.1%, P = 0.005) was associated with a 3-fold increase of liver cancer risk.
|
24269995 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 single-nucleotide polymorphism is known to promote nonalcoholic steatohepatitis (NASH), but its association with fibrosis severity and hepatocellular carcinoma (HCC) risk is less well-defined.
|
24445574 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriage of the PNPLA3 rs738409 C >G polymorphism is not only associated with greater risk of progressive steatohepatitis and fibrosis but also of HCC.
|
24607626 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 I148M sequence variant favors hepatic lipid accumulation and confers susceptibility to hepatic fibrosis and hepatocellular carcinoma.
|
25171251 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In end-stage liver disease patients, we identified ALD to be predominantly affected by the PNPLA3 I148M variant resulting in an increased risk of HCC and reduced transplantation free survival.
|
25273282 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In particular, the common I148M variant of the PNPLA3 gene influencing hepatic lipid metabolism influences HCC risk independently of its effect on the progression of liver fibrosis.
|
25278690 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown.
|
25504078 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 genetic polymorphism (rs738409 C>G) is associated with increased risk for the entire spectrum of ALD among drinkers including ALI, AC, and HCC.
|
25964223 |
2015 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on data from the HALT-C trial, the PNPLA3 CG/GG SNP at rs738409 is associated with fibrosis progression but not development of HCC in patients with HCV infection.
|
26305067 |
2016 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The SNP rs738409 located in PNPLA3 was the greatest risk factor associated with HCC.
|
26337813 |
2016 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I148M variant has a strong impact on the full spectrum of liver damage related to fatty liver, encompassing non-alcoholic steatohepatitis, advanced fibrosis, and hepatocellular carcinoma, and influences the response to therapeutic approaches.
|
26409295 |
2016 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study assessed the interaction between PNPLA3 rs738409 and TM6SF2 rs58542926 variants in the conditioning of HCC development.
|
26493626 |
2016 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis indicates that I148M polymorphism in the ADPN gene may independently contribute to the progression of HCC irrespective of the etiologies.
|
26632699 |
2015 |