|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
G allele carriers of the SNP rs738409 had higher liver fat (P < 0.0001) and an odds ratio of 2.38 (95% CI 1.37-4.20) for having fatty liver compared to C allele homozygotes.
|
19651814 |
2009 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults.
|
20546964 |
2010 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study identified genetic polymorphism (rs738409 C>G) in the PNPLA3/adiponutrin gene associated with liver steatosis.
|
21334404 |
2011 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNP rs738409 in PNPLA3 was significantly associated with liver density (P=0.0075) and hepatic steatosis (P=0.0350), but not with blood glucose, HbA(1c), total cholesterol, triglycerides, high-density or low-density lipoprotein levels or liver function tests (P=0.15-0.96).
|
21665509 |
2011 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single genetic variant, PNPLA3 I148M, has been widely associated with increased hepatic steatosis.
|
22978414 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
This gain of function provides a plausible biochemical mechanism for the development of liver steatosis in subjects carrying the I148M variant.
|
22560221 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Before 2008, candidate gene studies based on prior knowledge of pathophysiology of fatty liver yielded conflicting results.In 2008, Romeo et al. published the first genome wide association study and reported the strongest genetic signal for the presence of fatty liver (PNPLA3, patatin-like phospholipase domain containing 3; rs738409).
|
22093607 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP), the rs738409, in the patatin like phospholipase 3 gene (PNPLA3) has been recently associated with increased hepatic steatosis and ALT levels in adults and children.
|
22629460 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Expression of PNPLA3(I148M), but not PNPLA3(WT), in liver recapitulated the fatty liver phenotype as well as other metabolic features associated with this allele in humans.
|
23023705 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.
|
22898488 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies confirmed that the I148M variant predisposes towards the full spectrum of liver damage associated with fatty liver: from simple steatosis to steatohepatitis and progressive fibrosis.
|
24222941 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B.
|
23564580 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association between PNPLA3 rs738409/IL28B rs8099917 genotypes and hepatic steatosis or liver fibrosis was observed.
|
24349054 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as well as its pathobiological sequelae fibrosis, cirrhosis, and hepatocellular cancer.
|
24222094 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The amount of abdominal fat can increase the association of PNPLA3 p.I148M with liver steatosis.
|
23808989 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G allele of rs738409 (PNPLA3) and the T allele of rs780094 (GCKR) were associated with HS with a high level of ALT (odds ratio [OR], 1.36; P = .01; and OR, 1.30; P = .03, respectively).
|
23416328 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, we genotyped the same patients for the patatin-like phospholipase-containing domain 3 (PNPLA3) I148M polymorphism, which is implicated in the development of liver steatosis.
|
25250621 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
CT-defined fatty liver is common among men at risk for HIV infection and is associated with greater visceral adiposity, HOMA-IR, and PNPLA3 (rs738409).
|
24642579 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we show that only in subjects with hepatic steatosis, the OXFAs are associated with the CK-18 and that this association is modulated by the PNPLA3 rs738409 variant.
|
23815500 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hepatic steatosis and PNPLA3 I148M variant are associated with serum Fetuin-A independently of insulin resistance.
|
24828988 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A discrete trait analysis of NAFLD showed that rs58542926 was associated with a modest risk of fatty liver (P = 0.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless, conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect.
|
25302781 |
2015 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the patients with BMI < 24 kg/m(2), carriage of the rs738409 GG genotype was the only factor associated with hepatic steatosis (OR/CI:3.44/1.824-6.500, P < 0.001).
|
26139292 |
2015 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of PNPLA3 p.I148M with liver steatosis increased with the greater amount of abdominal fat, irrespective of BMI.
|
25986529 |
2015 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 variant influences histological liver damage in Japanese patients with chronic hepatitis C. The G allele homozygotes are at higher risk for hepatic steatosis, severe necroinflammation, and advanced fibrosis.
|
25543233 |
2015 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Impact of PNPLA3 rs738409 SNP on Liver Fibrosis Progression, Portal Hypertension and Hepatic Steatosis in HIV/HCV Coinfection.
|
26599080 |
2015 |