|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
G allele carriers of the SNP rs738409 had higher liver fat (P < 0.0001) and an odds ratio of 2.38 (95% CI 1.37-4.20) for having fatty liver compared to C allele homozygotes.
|
19651814 |
2009 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In patients with NAFLD, adiponutrin rs738409 C-->G genotype, encoding for I148M, is associated with the severity of steatosis and fibrosis and the presence of nonalcoholic steatohepatitis.
|
20373368 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 polymorphism is associated with steatosis severity, hepatocellular ballooning, lobular inflammation, and perivenular fibrosis in pediatric NAFLD.
|
20648474 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this large cohort of histologically proven NAFLD, we confirm the association of the rs738409 G allele with steatosis and describe its association with histological severity.
|
20684021 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The steatosis grade was not associated with rs738409.
|
21176169 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a case only analysis of G allele of rs738409 in PNPLA3 was associated with a decreased risk of zone 3 centered steatosis (OR = 0.46, 95% CI = 0.36-0.58; P = 5.15 x 10(-11)).
|
20648472 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults.
|
20546964 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs738409 PNPLA3 genotype influences steatosis development in CHC and is independently associated with cirrhosis and other steatosis-related clinical outcomes, such as lack of response to antiviral treatment and possibly HCC.
|
21319195 |
2011 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
An isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis.
|
22087248 |
2011 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNP rs738409 in PNPLA3 was significantly associated with liver density (P=0.0075) and hepatic steatosis (P=0.0350), but not with blood glucose, HbA(1c), total cholesterol, triglycerides, high-density or low-density lipoprotein levels or liver function tests (P=0.15-0.96).
|
21665509 |
2011 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs738409 SNP in PNPLA3 is associated with an increased risk of steatosis in patients infected with HCV genotypes non-3.
|
21236304 |
2011 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 (rs738409 C>G) polymorphism favors steatosis and fibrosis progression in CHC.
|
21488075 |
2011 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Frequencies of allele PNPLA3 rs738409(G) in individuals with steatosis and normal alanine aminotransferase (ALT) and AST levels were lower than in alcoholics without steatosis and normal ALT/AST (P(combined) = 0.03).
|
21254164 |
2011 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the impact of rs738409 on clinical and biological parameters, together with histological staging of steatosis and fibrosis.
|
21334404 |
2011 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies of the PNPLA3 I148M</span> sequence variant in HCV infected individuals have reported an association between this variant and prevalence of steatosis, fibrosis, and cirrhosis.
|
22978414 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the PNPLA3 p.I148M polymorphism influences steatosis and fibrogenesis in chronic hepatitis C (CHC).
|
22530607 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of the PNPLA3 I148M protein variant (p.I148M) with steatosis, fibrosis stage, and cirrhosis was evaluated by logistic regression analysis.
|
22719190 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs738409 GG genotype was associated with advanced fibrosis and steatosis, but not with HOMA-IR.
|
22634340 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Expression of PNPLA3(I148M), but not PNPLA3(WT), in liver recapitulated the fatty liver phenotype as well as other metabolic features associated with this allele in humans.
|
23023705 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 I148M variant is associated with the ultrasonography-determined steatosis degree in Chinese population.
|
23176674 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Before 2008, candidate gene studies based on prior knowledge of pathophysiology of fatty liver yielded conflicting results.In 2008, Romeo et al. published the first genome wide association study and reported the strongest genetic signal for the presence of fatty liver (PNPLA3, patatin-like phospholipase domain containing 3; rs738409).
|
22093607 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP), the rs738409, in the patatin like phospholipase 3 gene (PNPLA3) has been recently associated with increased hepatic steatosis and ALT levels in adults and children.
|
22629460 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis.
|
22724004 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.
|
22898488 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This gain of function provides a plausible biochemical mechanism for the development of liver steatosis in subjects carrying the I148M variant.
|
22560221 |
2012 |