rs752021744, PIK3CB

N. diseases: 29
Disease: Neoplasms ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.070 GeneticVariation BEFREE We analyzed tumor growth in mice that expressed the oncogenic form of KRAS (KRAS(G12D)) in pancreatic precursor cells, as well as sst2+/- and sst2-/-, and in crossed KRAS(G12D);sst2+/- and KRAS(G12D);sst2-/- mice. 25683115 2015
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.070 GeneticVariation BEFREE Furthermore, isoform-selective inhibitors showed a similar pattern of the isoform dependence in established Kras(G12D)/PTEN-deficient tumors. 24737887 2014
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.070 GeneticVariation BEFREE Most genes from this signature are also upregulated in poorly differentiated tumors developing in Pten(thyr-/-),Kras(G12D) mice. 23509868 2013
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.070 GeneticVariation BEFREE Treatment of Kras(G12D) mice with either of two distinct small molecule Pak inhibitors (PF3758309 and FRAX597) caused tumor regression and loss of Erk and Akt activity. 22983922 2012
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.070 GeneticVariation BEFREE Finally, m-CT imaging in live Kras(G12D-LSL) mice showed reduction of tumor burdens in PD-0325901-treated animals at sub-MTD dose. 22684718 2012
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.070 GeneticVariation BEFREE Moreover, we show that KRAS(G12D)- and BRAF(V600E)-induced tumor formation in an orthotopic model requires IGF1R. 22871572 2012
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.070 GeneticVariation BEFREE In LSL-K-ras(G12D/+)Pten(loxP/loxP) mice with established intraperitoneal tumor disease, oral administration of NVP-BEZ235 decreased pAkt, p4E-BP1 and Ki67 in tumor tissue, and resulted in significantly longer survival compared to control animals (P < 0.05). 21372221 2011