|
Hypertensive disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Because hypertension is considered to be a complex disorder resulting from interactions between genetic and environmental factors, we further analyzed the T393C polymorphism, with consideration of interactions between the polymorphism and confounding factors in regression models.
|
12215464 |
2002 |
|
Hypertensive disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Because alcohol consumption is known to affect blood pressure partly through the beta-AR-Gs protein system, we examined the possible interaction between GNAS1 T393C polymorphism and drinking status in the association with hypertension in the present study.
|
12862199 |
2003 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The T393C polymorphism of the G alpha s gene (GNAS1) is a novel prognostic marker in bladder cancer.
|
15824158 |
2005 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The T393C polymorphism of the G alpha s gene (GNAS1) is a novel prognostic marker in bladder cancer.
|
15824158 |
2005 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The T393C polymorphism of the G alpha s gene (GNAS1) is a novel prognostic marker in bladder cancer.
|
15824158 |
2005 |
|
TARSAL-CARPAL COALITION SYNDROME
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the role of the GNAS1 locus encoding G(alpha)s as a genetic factor for disease progression of transitional cell carcinoma (TCC) of the bladder, we genotyped the synonymous T393C polymorphism in 254 patients with TCC (minor allele frequency: 0.43) to examine a potential association between genotypes and disease progression.
|
15824158 |
2005 |
|
Carcinoma, Transitional Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the role of the GNAS1 locus encoding G(alpha)s as a genetic factor for disease progression of transitional cell carcinoma (TCC) of the bladder, we genotyped the synonymous T393C polymorphism in 254 patients with TCC (minor allele frequency: 0.43) to examine a potential association between genotypes and disease progression.
|
15824158 |
2005 |
|
Hypertensive disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
These results did not support the hypothesis that the interaction between the T393C polymorphism and GGT in the association with hypertension could be caused by an indirect effect of Gs proteins mediated by glucose metabolism.
|
15894831 |
2004 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, analysis of the possible interaction of the T393C polymorphism with GGT in the association with diabetes mellitus or fasting plasma glucose failed to show a significant result.
|
15894831 |
2004 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have recently shown an association between the GNAS1 T393C polymorphism and disease progression in patients with bladder cancer with homozygous TT genotypes displaying increased transcription of Galpha s and a more favorable clinical course compared with C-allele carriers.
|
16033819 |
2005 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have recently shown an association between the GNAS1 T393C polymorphism and disease progression in patients with bladder cancer with homozygous TT genotypes displaying increased transcription of Galpha s and a more favorable clinical course compared with C-allele carriers.
|
16033819 |
2005 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have recently shown an association between the GNAS1 T393C polymorphism and disease progression in patients with bladder cancer with homozygous TT genotypes displaying increased transcription of Galpha s and a more favorable clinical course compared with C-allele carriers.
|
16033819 |
2005 |
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results support the role of the T393C polymorphism as a marker for survival in patients with colorectal cancer stages I to II and in the identification of patients who may benefit from adjuvant chemotherapy.
|
16033819 |
2005 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results support the role of the T393C polymorphism as a marker for survival in patients with colorectal cancer stages I to II and in the identification of patients who may benefit from adjuvant chemotherapy.
|
16033819 |
2005 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Altogether, our data suggest that the GNAS1 T393C status could influence susceptibility for deficit schizophrenia in Italian subjects.
|
16406317 |
2006 |
|
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results show that besides tumor stage, lymph node status, and tumor grade, the GNAS1 T393C status is a novel independent host factor for disease progression in patients with clear cell renal cell carcinoma and provides further evidence for the T393C polymorphism as a general prognostic tumor marker.
|
16467086 |
2006 |
|
Tumor Progression
|
|
0.030 |
GeneticVariation
|
BEFREE |
Kaplan-Meier curves for tumor progression, development of metastasis, and tumor-related death showed a significant association of the T393C polymorphism with outcome (5-year cancer-specific survival rates: TT, 91%; TC, 81%; CC, 69%; P = 0.015).
|
16467086 |
2006 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results show that besides tumor stage, lymph node status, and tumor grade, the GNAS1 T393C status is a novel independent host factor for disease progression in patients with clear cell renal cell carcinoma and provides further evidence for the T393C polymorphism as a general prognostic tumor marker.
|
16467086 |
2006 |
|
Chronic Lymphocytic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here, we show that the GNAS1 T393C status is a novel independent prognostic marker in patients with B-CLL.
|
17020971 |
2006 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we show that the GNAS1 T393C status is a novel independent prognostic marker in patients with B-CLL.
|
17020971 |
2006 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The T393C polymorphism is not associated with PCOS in Caucasian women, but may represent a genetic marker for increased susceptibility for obesity in this cohort.
|
17062894 |
2006 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The T393C polymorphism is not associated with PCOS in Caucasian women, but may represent a genetic marker for increased susceptibility for obesity in this cohort.
|
17062894 |
2006 |
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have recently shown that genotypes of the single nucleotide polymorphism (SNP) T393C in the gene GNAS1 are associated with survival of patients suffering from bladder, renal cell and colorectal carcinoma.
|
17186357 |
2007 |
|
Invasive carcinoma of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that the GNAS1 T393C SNP is a novel genetic host factor for disease progression in patients with invasive breast carcinoma.
|
17186357 |
2007 |
|
Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our finding that TT homozygosity (and not CC homozygosity) was associated with unfavorable clinical outcome points to the complex and differing functional effects induced by GNAS1 T393C polymorphism in various human carcinomas.
|
17356712 |
2007 |