|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to develop a simple, fast and accurate new method for detecting the Val66Met polymorphism of the BDNF gene in schizophrenia patients using melting-curve analysis and a DNA-specific dye, SYBR Green I.
|
19530966 |
2009 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment.
|
12951204 |
2003 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val66 met polymorphism.
|
15719396 |
2005 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine, by meta-analysis, if the Val66Met polymorphism of BDNF influences risk for either schizophrenia, bipolar disorder, or both.
|
17417060 |
2007 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, in a meta-analysis, the Val66Met polymorphism was not associated with schizophrenia, whereas C270T showed a trend for association in a fixed model (p=0.036), but not in a random model (p=0.053).
|
19406621 |
2009 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single base pair polymorphism (BDNF Val66Met) was reported to be associated with AD and/or schizophrenia, as well as other psychoses, although some studies failed to replicate these findings.
|
21044653 |
2011 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggested an association between BDNF Val66Met polymorphism and OCS in Egyptian schizophrenia patients.
|
22521161 |
2012 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To characterize the neurocognitive and brain morphometric phenotypic correlates of the BDNF Val66Met polymorphism and to test the specificity of the BDNF(Met) variant on cognitive dysfunction in schizophrenia.
|
16818862 |
2006 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether the Val66Met polymorphism of the BDNF gene affected weight gain after long-term antipsychotic treatment in schizophrenia.
|
17987059 |
2008 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies have also shown that the BDNF Val66Met polymorphism was associated with weight gain in patients with schizophrenia on long-term antipsychotic treatment.
|
27483421 |
2016 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we investigated whether val66met, a functional and abundant missense polymorphism in the coding region of the BDNF gene, was associated with the volume of the hippocampal formation in 19 patients with first-episode schizophrenia and 25 healthy volunteers.
|
15768049 |
2005 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between BDNF Val66Met polymorphism and cognitive performance in antipsychotic-naïve patients with schizophrenia.
|
22477643 |
2012 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our population-based study and meta-analysis demonstrate that the BDNF C-270T and Val66Met polymorphisms do not play major roles in the susceptibility to schizophrenia in either Caucasian or Asian populations.
|
17289348 |
2007 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism, which results in deficient activity-dependent secretion of BDNF, is associated with clinical features of schizophrenia.
|
27262112 |
2017 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analyses did not robustly establish an association between BDNF Val66Met polymorphism and neurocognition in schizophrenia.
|
25681004 |
2015 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This differential response to fetal hypoxia was specific to schizophrenia and was not explained by other obstetric complications or by the BDNF valine (val) to methionine (met) polymorphism at codon 66 (val66met).
|
18486103 |
2008 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies will be required in this area to confirm the effect of the BDNF Val66Met polymorphism in the pathophysiology of schizophrenia and patients' response to antipsychotic drugs, especially in a larger sample size and in different ethnic populations.
|
30312750 |
2018 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Data from several recent studies have also converged showing that the val66met allele of BDNF, a common single nucleotide polymorphism (SNP), is associated with selective minor deficits in cognitive functioning in subjects with schizophrenia, bipolar illness, and normal controls.
|
17239400 |
2007 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The brain derived neurotrophic factor (BDNF) val66met polymorphism rs6265 influences learning and may represent a risk factor for schizophrenia.
|
25125238 |
2014 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We argue that while the Val66Met polymorphism may not be a major risk-conferring agent for the development of schiz</span>ophrenia per se, there is mounting evidence that the polymorphism modulates a range of clinical features of the illness, including age of onset, symptoms, therapeutic responsiveness, neurocognitive function and brain morphology.
|
25562189 |
2015 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met genotyping was performed in 27 matched pairs of schizophrenia and comparison subjects.
|
16513879 |
2006 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients.
|
29898578 |
2018 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia.
|
23319002 |
2013 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant association between BDNF Val66Met polymorphism and schizophrenia in our meta-analysis study.
|
26134309 |
2016 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the BDNF Val66Met polymorphism may affect a smoker's response to nicotine in both schizophrenia and healthy controls from a Chinese Han population, but with differential effects in different aspects of smoking behaviors.
|
25455509 |
2015 |