|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism should be considered as a potential moderator of clinical trial outcomes in current treatment and prevention trials in DIAD and sporadic AD.Ann Neurol 2018;84:424-435.
|
30014553 |
2018 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study examined potential association between single nucleotide polymorphisms (SNPs) of the BDNF gene (G11757 C, C270T, G196A, G-712A) and Alzheimer's disease-related depression (AD-D).
|
21677379 |
2011 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The gene variants of the BDNF Val66Met polymorphism were significantly associated with the presence of psychotic symptoms in male, but not in female patients with AD.
|
21044653 |
2011 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cognitive decline in AD.
|
16627933 |
2006 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the <i>BDNF</i> Val66Met polymorphism may play an important role in cognitive decline and could be considered as a target for novel AD therapeutics.
|
28468845 |
2017 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis confirmed the gender-related association between BDNF 196A/G polymorphism and AD risk, which may indicate a certain effect of female hormone on progression of the disease.
|
24279351 |
2014 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To date, there have been several conflicting reports on the correlation between AD or PD and Val66Met or C270T polymorphism in the BDNF promoter region, although no data on this relationship have been published with respect to dementia with Lewy bodies (DLB).
|
16899999 |
2006 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether the BDNF Val66Met gene variant interacts with age to predict brain and cognitive measures in healthy volunteers across the adult lifespan in an intermediate phenotype pattern related to AD by examining (1) cortical thickness, (2) fractional anisotropy of white matter tracts (ie, white matter integrity), and (3) episodic memory performance.
|
21300947 |
2011 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To study the role of BDNF 196 G>A and 270 C>T polymorphisms in Finnish AD and PD patients we genotyped BDNF 196 G>A and 270 C>T polymorphisms in 97 sporadic AD patients, 52 PD patients and 101 control subjects with polymerase chain reaction.
|
16565926 |
2006 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Understanding the role of brain-derived neurotrophic factor (BDNF) in synaptic plasticity and synaptogenesis, the impact of the BDNF Val66Met polymorphism in Alzheimer's disease-relevant endophenotypes - including episodic memory and hippocampal volume - and the technological progress in measuring synaptic changes in humans all pave the way for a 'synaptic repair' therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis.
|
23674053 |
2013 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We also tested BDNF Val66Met-C270T haplotypes for an interaction with the apolipoprotein E upsilon4 (APOE4) allele in AD.
|
16391475 |
2006 |