rs762846821, TP53

N. diseases: 57
Disease: Pancreatic intraepithelial neoplasia ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Pancreatic intraepithelial neoplasia
CUI: C1301034
Disease: Pancreatic intraepithelial neoplasia
0.020 GeneticVariation BEFREE Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48(Cre/+)-LSL-Kras(G12D/+) mice. 23019409 2012
Pancreatic intraepithelial neoplasia
CUI: C1301034
Disease: Pancreatic intraepithelial neoplasia
0.020 GeneticVariation BEFREE Mice with pancreas-specific tsTAg expression developed acinar cell dysplasia by 22 weeks without PanIN formation, while mice expressing both tsTAg and Kras(G12D) developed highly aggressive adenocarcinoma with a ductal cell phenotype within a short period, and died within 3 weeks. 25042889 2014