|
Secondary Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individuals with the C634R mutation presented significantly more distant metastases at diagnosis than subjects with the C634Y or C634W mutations (54.5% vs. 19.4% vs. 14.3%, respectively, P = 0.03).
|
12788868 |
2003 |
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individuals with the C634R mutation presented significantly more distant metastases at diagnosis than subjects with the C634Y or C634W mutations (54.5% vs. 19.4% vs. 14.3%, respectively, P = 0.03).
|
12788868 |
2003 |
|
C-cell hyperplasia of thyroid
|
|
0.010 |
GeneticVariation
|
BEFREE |
Sequencing analysis of the RET proto-oncogene revealed a Cys634Trp (TGC->TGG) mutation in all clinically affected family members and in an asymptomatic 5-year-old child who, after thyroidectomy, was found to have multicentric medullary thyroid carcinoma and C-cell hyperplasia.
|
11939755 |
2002 |
|
Thyroid Neoplasm
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial.
|
22025146 |
2012 |
|
Thyroid Neoplasm
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Thyroid cancer cell lines harboring RET/PTC1 (TPC-1), RET M918T (MZ-CRC1) and RET C634W (TT) alterations, as well as TPC-1 xenografts, were treated with JAK inhibitor, AZD1480.
|
23056499 |
2012 |
|
Thyroid Neoplasm
|
|
0.700 |
GeneticVariation
|
CLINVAR |
The effects of four different tyrosine kinase inhibitors on medullary and papillary thyroid cancer cells.
|
21470995 |
2011 |
|
Thyroid Neoplasm
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer.
|
20065189 |
2010 |
|
Multiple Endocrine Neoplasia Type 2b
|
|
0.700 |
GeneticVariation
|
CLINVAR |
RET activation by germline MEN2A and MEN2B mutations.
|
8570194 |
1995 |
|
Multiple Endocrine Neoplasia, Type IV
|
|
0.700 |
GeneticVariation
|
CLINVAR |
RET activation by germline MEN2A and MEN2B mutations.
|
8570194 |
1995 |
|
Multiple Endocrine Neoplasia Type 1
|
|
0.700 |
GeneticVariation
|
CLINVAR |
RET activation by germline MEN2A and MEN2B mutations.
|
8570194 |
1995 |
|
Multiple endocrine neoplasia Type 2
|
|
0.710 |
CausalMutation
|
CLINVAR |
Surgery in MEN 2A Patients Older Than 5 Years with Micro-MTC: Outcome at Long-term Follow-up.
|
27406704 |
2016 |
|
Multiple endocrine neoplasia Type 2
|
|
0.710 |
CausalMutation
|
CLINVAR |
Genetics of pheochromocytoma and paraganglioma in Spanish pediatric patients.
|
23404858 |
2013 |
|
Multiple endocrine neoplasia Type 2
|
|
0.710 |
GeneticVariation
|
BEFREE |
Three different known RET germline mutations in exon 11 (codon 634), p.Cys634Arg (c1900 T-->C) (de novo case), p.Cys634Phe (c1901 G-->T), p.Cys634Trp (c1902 C-->G), were detected in three individuals with MEN2 phenotype.
|
19841562 |
2010 |
|
Multiple endocrine neoplasia Type 2
|
|
0.710 |
CausalMutation
|
CLINVAR |
Age-related neoplastic risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germ line RET Cys634Trp (TGC>TGG) mutation.
|
18794325 |
2008 |
|
Multiple endocrine neoplasia Type 2
|
|
0.710 |
CausalMutation
|
CLINVAR |
Evidence of MEN-2 in the original description of classic pheochromocytoma.
|
17898100 |
2007 |
|
Familial medullary thyroid carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
The patient with FMTC had a mutation in codon 634 (C634W).
|
15588376 |
2004 |
|
Multiple endocrine neoplasia Type 2
|
|
0.710 |
CausalMutation
|
CLINVAR |
RET codon 634 mutations in multiple endocrine neoplasia type 2: variable clinical features and clinical outcome.
|
12788868 |
2003 |
|
Multiple endocrine neoplasia Type 2
|
|
0.710 |
CausalMutation
|
CLINVAR |
Early onset of medullary thyroid carcinoma in a kindred with multiple endocrine neoplasia type iia associated with cutaneous lichen amyloidosis.
|
11939755 |
2002 |
|
Familial medullary thyroid carcinoma
|
|
0.710 |
GeneticVariation
|
UNIPROT |
Three novel mutations in the RET proto-oncogene.
|
11692159 |
2001 |
|
Familial medullary thyroid carcinoma
|
|
0.710 |
GeneticVariation
|
UNIPROT |
A RET double mutation in the germline of a kindred with FMTC.
|
10826520 |
2000 |
|
Familial medullary thyroid carcinoma
|
|
0.710 |
GeneticVariation
|
UNIPROT |
A novel 9-base pair duplication in RET exon 8 in familial medullary thyroid carcinoma.
|
10323403 |
1999 |
|
Familial medullary thyroid carcinoma
|
|
0.710 |
GeneticVariation
|
UNIPROT |
A GTG to ATG novel point mutation at codon 804 in exon 14 of the RET proto-oncogene in two families affected by familial medullary thyroid carcinoma.
|
9452077 |
1998 |
|
Familial medullary thyroid carcinoma
|
|
0.710 |
GeneticVariation
|
UNIPROT |
Mutational analysis of the RET proto-oncogene in 71 Japanese patients with medullary thyroid carcinoma.
|
9621513 |
1998 |
|
Familial medullary thyroid carcinoma
|
|
0.710 |
GeneticVariation
|
UNIPROT |
A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A.
|
9506724 |
1998 |
|
Familial medullary thyroid carcinoma
|
|
0.710 |
GeneticVariation
|
UNIPROT |
Novel point mutation in exon 10 of the RET proto-oncogene in a family with medullary thyroid carcinoma.
|
9677065 |
1998 |