|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results provide evidence that the T risk allele in TCF7L2 rs7903146 is associated with failure in early postprandial glycemic control and requirement of insulin therapy in women with gestational diabetes mellitus, even after adjusting for confounding factors such BMI and age.
|
31546272 |
2019 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
For the first time, we identified eight variants associated with GDM, namely rs7957197 (HNF1A), rs10814916 (GLIS3), rs3802177 (SLC30A8), rs9379084 (RREB1), rs34872471 (TCF7L2), rs7903146 (TCF7L2), rs11787792 (GPSM1) and rs7041847 (GLIS3).
|
29947923 |
2018 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, the additional presence of TCF7L2 rs7903146 risk alleles does not further aggravate the negative impact of a history of gestational diabetes on metabolic traits related to T2DM.
|
30419301 |
2018 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic variant rs7903146 (C > T) in TCF7L2 gene showed a strong association with GDM risk (OR: 2.56; 95% CI: [1.24-5.29]).
|
29325775 |
2018 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significantly increased GD</span>M risk was observed for TCF7L2 rs7903146 (all OR > 1, p < 0.01), but not rs12255372.
|
28277135 |
2017 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Six of eight SNPs were found to have significant associations between TCF7L2 variants and GDM risk in the overall population, with the most powerful in SNPs being rs7903146, rs12255372 and rs7901695, but the contribution of these SNPs to GDM risk were variable among different racial/ethnic groups.
|
28002648 |
2017 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings support the association between <i>TCF7L2</i> rs7903146 variant and an increased GDM risk.
|
28133617 |
2017 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The OGTT test using 100 g, but not 75 g; and genotype detection by other assays, but not Taqman method, were also significantly associated with increased GDM risk in rs1801278(IRS1) and rs7903146(TCF7L2).
|
27468700 |
2016 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that the T allele of TCF7L2 rs7903146 polymorphism was associated with susceptibility of GDM in overall population in white, Hispanic/Latino and Asian sub-groups.
|
27058589 |
2016 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the association between fat mass and obesity-associated (FTO) gene polymorphisms rs8050136C>A and rs9939609T>A, and transcription factor 7-like 2 (TCF7L2) gene polymorphisms rs12255372G>T and rs7903146C>T, in a sample group of pregnant Euro-Brazilian women with or without gestational diabetes mellitus (GDM).
|
26102344 |
2015 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the healthy and GDM pregnant women groups, the A-allele frequencies (95% CI) of FTO polymorphisms rs8050136 and rs9939609 were 39% (34-44%); 38% (33-43%) and 40% (35-45%); 41% (36-46%), respectively; and the T-allele frequencies of TCF7L2 polymorphisms rs12255372 and rs7903146 were 30% (26-35%), 32% (27-37%) and 29% (25-34%), 36% (31-41%), respectively.
|
26102344 |
2015 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR, rs7903146 of TCF7L2 and rs11708067 of ADCY5 showed nominally significant associations with GDM (OR range from 1.25 to 1.30).
|
23761423 |
2013 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis suggests that TCF7L2 rs7903146 genetic polymorphism was associated with increased risk of gestational diabetes mellitus.
|
23855352 |
2013 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among them, genetic variants in TCF7L2 showed the strongest association with GDM risk, with ORs (95% CIs) of 1.44 (1.29-1.60, P < 0.001) per T allele of rs7903146 and 1.46 (1.15-1.84, P = 0.002) per T allele of rs12255372.
|
23690305 |
2013 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
These polymorphisms were in or near the following genes: TCF7L2 (rs7903146), MTNR1B (rs10830963), IGF2BP2 (rs4402960), KCNJ11 (rs5219), CDKAL1 (rs7754840), KCNQ1 (rs2237892 and rs2237895) and GCK (rs4607517); while no association was found for PPARG with GDM risk.
|
23029294 |
2012 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The heterozygous genotypes CT, GT and TC of the rs7903146 (T is risk for Type 2 diabetes), rs12255372 (T is risk for Type 2 diabetes) and rs7901695 (C is risk for Type 2 diabetes), respectively, as well as the homozygous genotypes TT, TT and CC of the rs7903146, rs12255372 and rs7901695, respectively, were strongly associated with gestational diabetes (P < 0.0001).
|
21672010 |
2011 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women.
|
20540670 |
2011 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Compared with controls (men and women combined), GDM was associated with rs7756992 and rs7754840 (OR 1.55, 95% CI 1.34-1.79, p = 4.17 x 10(-9)) in CDKAL1; rs10811661 (OR 1.49, 95% CI 1.29-1.72, p = 1.05 x 10(-7)) in the CDKN2A-CDKN2B region; rs1111875 (OR 1.27, 95% CI 1.09-1.49, p = 0.003), rs5015480, and rs7923837 in HHEX; rs4402960 (OR 1.18, 95% CI 1.01-1.38, p = 0.03) in IGF2BP2; rs13266634 (OR 1.24, 95% CI 1.07-1.43, p = 0.005) in SLC30A8; and rs7903146 (OR 1.58, 95% CI 1.03-2.43, p = 0.038) in TCF7L2.
|
19002430 |
2009 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TCF7L2 rs7903146 variant is associated with an increased risk of gestational diabetes mellitus in Scandinavian women.
|
17342473 |
2007 |