|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association was observed in HCV mono-infected (OR, 2.49; 95% CI, 1.64-3.79; P = 1.96 x 10(-5)) and HCV/HIV coinfected individuals (OR, 2.16; 95% CI, 1.47-3.18; P = 8.24 x 10(-5)). rs8099917 was also associated with failure to respond to therapy (OR, 5.19; 95% CI, 2.90-9.30; P = 3.11 x 10(-8)), with the strongest effects in patients with HCV genotype 1 or 4.
|
20060832 |
2010 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms were genotyped in the IL28B locus (rs12979860 and rs8099917) from 817 patients with chronic HCV infection, and substitutions at amino acids 70 and 91 of the HCV core protein and within the NS5A interferon sensitivity-determining region (ISDR) were analysed.
|
21068134 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common IL28B locus polymorphisms (SNPs rs8099917 and rs12979860) have been reported to affect peg-interferon plus ribavirin combination therapy (PEG-RBV) for hepatitis C virus (HCV) genotype 1b, but few reports have examined their effect on other two common genotypes, 2a and 2b.
|
21112660 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
With rs8099917, HCV genotype 1b patients had a significantly lower frequency of the favourable genotype (86.6 %) compared with healthy controls (91.7 %), and HCV genotype 2a patients had an intermediate frequency (89.9 %).
|
21228123 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs8099917 TT genotype is significantly independently predictive of RVR, which is the single best predictor of SVR, in Asian HCV-2 patients.
|
21254157 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that the HCV genotype 1 responder genotypes at rs12979860 and rs8099917 did not associate with sustained virological response to PEG-IFN/ribavirin therapy.
|
21374656 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Correlation analysis revealed that rs8099917 genotype was correlated with γ-glutamyl transpeptidase, hyaluronic acid, and HCV core aa 70.
|
21503910 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The purpose of the study was to establish methods for determining the SNP rs8099917 associated with IL28B, which might be useful for further research of the treatment of HCV.
|
21529139 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among patients with HCV genotype 1b, there were differences in the reduction and subsequent increase in HCV RNA levels after administering IFN based on rs8099917 genetic polymorphisms.
|
21567424 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients carrying both CC(rs12979860) and TT(rs8099917) genotypes achieved lower levels of HCV RNA at week 4 than those with CT or TT at rs12979860 and TT(rs8099917) (P = 0.0004).
|
21692944 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies have identified two host single-nucleotide polymorphisms (SNPs) near the IL28B gene (rs12979860 C/T and rs8099917 T/G) that are associated with sustained virological response in patients infected with the hepatitis C virus.
|
21704279 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In particular, serum apoB-100 concentration might be an informative marker for judging changes in HCV-associated intracellular lipoprotein metabolism in patients carrying the rs8099917 responder genotype.
|
21879313 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine whether a single IL-28B genotype SNP rs8099917 or rs12979860 determination is sufficient to predict treatment failure in patients with chronic HCV.
|
21900787 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The allelic discrimination assay by Taqman real-time PCR was developed to determine genotypes of SNPs, rs12979860 and rs8099917, which were analyzed in 65 Korean patients with HCV genotype-1.
|
21907615 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL28B SNP rs8099917 "G" was associated with absence of treatment-induced clearance (odds ratio [OR] 2.19, p = 1.27×10(-8), 1.67-2.88) and absence of spontaneous clearance (OR 3.83, p = 1.71×10(-14), 2.67-5.48) of HCV, as was rs12979860, with slightly lower ORs.
|
21931540 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among 1369 Urban Health Study participants, we evaluated genetic models for the association of IL28B genotype (rs12979860 and rs8099917) with hepatitis C virus (HCV) clearance.
|
22013224 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotypes of the IL-28B rs8099917 T>G single nucleotide polymorphism were determined in 177 patients with HCV infection.
|
22052088 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among patients with the TT genotype for rs8099917 (associated with a favorable response), the rates of sustained virologic response were higher in patients with a ≥3 log(10) reduction in serum HCV RNA levels at 4 weeks after starting therapy (P < 0.0001).
|
22095536 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL28B rs12979860 and rs8099917 polymorphisms were predictors of therapy response in HCV genotypes 1, 2 and 3 subjects from an admixed population.
|
22098416 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs8099917 genotype and total PEG-IFN dose were associated with SVR in patients with hepatitis C virus genotype 1.
|
22156487 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess whether the IL28B rs8099917 SNP also affects the progression of chronic HCV infection, we genotyped 511 Japanese HCV patients, including 69 with hepatocellular carcinoma (HCC).
|
22245236 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNP, rs8099917, rs12979860) near the IL28B gene have been illustrated as outcome predictors of hepatitis C virus (HCV) treatment with pegylated interferon/ribavirin.
|
22257210 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results demonstrate that rs12979860, compared to rs8099917, may be a better predictor of response to the peg-IFN/RBV treatment among HCV/HIV-1 coinfected patients.
|
22328925 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four SNPs were significantly associated with spontaneous HCV clearance: rs8099917 TT (vs GT), rs8105790 TT (vs CT), rs12980275 AA (vs AG) and rs10853728 CC (vs CG or GG) with OR (95% CI) 15.27 (2.07-112.50), 14.88 (2.02-109.72), 7.92 (1.88-33.32) and 2.32 (1.22-4.42) respectively.
|
22329371 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our research was to clarify study whether IL-28B gene polymorphism (rs8099917) is associated with HTLV-1/HCV co-infection.
|
22336134 |
2012 |