|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
|
19349983 |
2009 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
|
19349983 |
2009 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents.
|
28119119 |
2017 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population.
|
28613373 |
2017 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
GWASCAT |
A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.
|
24940741 |
2014 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance.
|
24846544 |
2014 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population.
|
21408128 |
2011 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B.
|
21346778 |
2011 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Association between rs9277535 and HCC susceptibility was examined in five separate comparisons that contained 2017 cases and 3930 carriers.
|
26634522 |
2015 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
However, the experiment showed that HLA-DP rs3077, rs9277535 and rs7453920 did not associate with HCC development (dominant model, rs3077, OR = 0.86, 95%CI = 0.62-1.18; rs9277535, OR = 0.94, 95%CI = 0.68-1.30; rs7453920, OR = 0.75, 95%CI = 0.44-1.27).
|
25365208 |
2014 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
The interaction of rs9277535 AA with the T1674C/G or G1719T mutation in genotype C significantly decreased HCC risk.
|
24006435 |
2013 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Logistic regression analyses showed that HLA-DQ rs2856718 significantly decreased host HCC risk, whereas three SNPs were associated with HBV clearance (HLA-DP rs9277535 as well as HLA-DQ rs7453920 and rs2856718).
|
22105689 |
2012 |
|
cervical cancer
|
|
0.720 |
GeneticVariation
|
BEFREE |
<i>Conclusion.</i> HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.
|
30009173 |
2018 |
|
cervical cancer
|
|
0.720 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
|
23817570 |
2013 |
|
cervical cancer
|
|
0.720 |
GeneticVariation
|
BEFREE |
These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females.
|
23428460 |
2013 |
|
Rheumatoid Arthritis
|
|
0.710 |
GeneticVariation
|
BEFREE |
Allele A of rs9277535 in HLA-DP correlated to increased risk of RA and elevated serum anti-CCP level.
|
29476350 |
2018 |
|
Rheumatoid Arthritis
|
|
0.710 |
GeneticVariation
|
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Rheumatoid Arthritis
|
|
0.710 |
GeneticVariation
|
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
Complete atrioventricular block
|
|
0.040 |
GeneticVariation
|
BEFREE |
rs1883832 serves as a valuable predictive factor for CHB patients with HBeAg seroconversion. rs9277535 at HLA-DP might also be a valuable predictive factor for CHB patients with HBeAg-negative, however, further verifications are recommended due to study limitations.
|
29451182 |
2018 |
|
Complete atrioventricular block
|
|
0.040 |
GeneticVariation
|
BEFREE |
Additionally, we validated seven of eight previously reported CHB susceptibility loci (rs3130542 at HLA-C, rs1419881 at TCF19, rs652888 at EHMT2, rs2856718 at HLA-DQB1, rs7453920 at HLA-DQB2, rs3077 at HLA-DPA1, and rs9277535 at HLA-DPA2, which are all located in the HLA region, 9.84 × 10(-71) ≤ Pmeta ≤ 9.92 × 10(-7) ).
|
25802187 |
2015 |