Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 1
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 20
AURKA O14965 aurora kinase A Kinase 0.87 0.475 0.731 2
AXIN1 O15169 axin 1 0.41 0.559 0.577 8
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 14
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 16
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808 5
EPHB2 P29323 EPH receptor B2 Kinase 1.00 0.374 0.846 1
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 28
FANCA O15360 FA complementation group A 1.6E-68 0.505 0.731 3
FOXA1 P55317 forkhead box A1 Transcription factor 0.22 0.522 0.731 5
HDAC2 Q92769 histone deacetylase 2 Epigenetic regulator 1.00 0.476 0.846 1
KLF6 Q99612 Kruppel like factor 6 Nucleic acid binding 0.98 0.501 0.846 8
MAD1L1 Q9Y6D9 mitotic arrest deficient 1 like 1 6.8E-16 0.570 0.731 2
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 6
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 8
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
SPOP O43791 speckle type BTB/POZ protein 1.00 0.597 0.500 4