Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1277 41
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 999 26
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 765 17
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 581 22
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 535 18
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 517 111
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 462 37
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 453 81
WNK1 Q9H4A3 WNK lysine deficient protein kinase 1 Kinase 1.00 0.416 0.846 407 9
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 403 23
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 399 30
PDGFRA P16234 platelet derived growth factor receptor alpha Kinase 1.00 0.415 0.808 383 23
SETD2 Q9BYW2 SET domain containing 2, histone lysine methyltransferase Epigenetic regulator 1.00 0.424 0.846 353 3
JAG1 P78504 jagged canonical Notch ligand 1 1.00 0.429 0.808 322 5
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 314 1
BRD4 O60885 bromodomain containing 4 Epigenetic regulator 1.00 0.446 0.885 296 2
PRKCB P05771 protein kinase C beta Kinase 1.00 0.453 0.885 288 6
DICER1 Q9UPY3 dicer 1, ribonuclease III Enzyme 1.00 0.446 0.846 271 8
CUX1 P39880 Q13948 cut like homeobox 1 Transcription factor 1.00 0.465 0.846 268 12
FLT4 P35916 fms related receptor tyrosine kinase 4 Kinase 1.00 0.457 0.808 266 5
HDAC6 Q9UBN7 histone deacetylase 6 Epigenetic regulator 1.00 0.465 0.846 254 0
TEK Q02763 TEK receptor tyrosine kinase Kinase 1.00 0.462 0.692 248 5
TSC1 Q92574 TSC complex subunit 1 1.00 0.440 0.808 248 12
COL1A1 P02452 collagen type I alpha 1 chain 1.00 0.430 0.808 238 38