Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 98 61
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 109 1
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
ALB P02768 albumin Transporter 0.64 0.317 0.962 123 9
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 138 40
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 101 18
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 83 37
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 69 3
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 96 6
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 91 10
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 119 20
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 110 65
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 44 5
CD44 P16070 CD44 molecule (Indian blood group) 2.4E-07 0.363 0.962 31 16
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 95 596
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 92 30