Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 16
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 7
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 3
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 17
WT1 P19544 WT1 transcription factor Nucleic acid binding 1.00 0.422 0.808 3
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808 9
RUNX1 Q01196 RUNX family transcription factor 1 Transcription factor 0.65 0.425 0.808 1
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808 4
IDH2 P48735 isocitrate dehydrogenase (NADP(+)) 2 0.88 0.434 0.808 5
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 15
DNMT3A Q9Y6K1 DNA methyltransferase 3 alpha 7.4E-39 0.445 0.846 1
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 12
FLT3 P36888 fms related receptor tyrosine kinase 3 Kinase 0.61 0.462 0.654 2
NPM1 P06748 nucleophosmin 1 Chaperone 1.00 0.464 0.846 3
CUX1 P39880 Q13948 cut like homeobox 1 Transcription factor 1.00 0.465 0.846 9
BCOR Q6W2J9 BCL6 corepressor 1.00 0.471 0.808 2
JAK1 P23458 Janus kinase 1 Kinase 1.00 0.474 0.769 3
ETV6 P41212 ETS variant transcription factor 6 Transcription factor 0.97 0.477 0.731 1
FANCD2 Q9BXW9 FA complementation group D2 1.1E-30 0.479 0.885 2
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 8
CEBPA P49715 CCAAT enhancer binding protein alpha Transcription factor 0.55 0.496 0.692 2