Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 209
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 255
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 254
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 337
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 119
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 125
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 73
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 29
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 59
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 131
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 70
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 303
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 74
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 83
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 176
LMNA P02545 lamin A/C 1.00 0.384 0.885 425
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 154
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 186
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 264
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 141
PTCH1 Q13635 patched 1 1.00 0.398 0.885 143
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808 81
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 132
COX8A P10176 cytochrome c oxidase subunit 8A Enzyme 0.12 0.400 0.846 37