Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 95
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 209
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 128
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 255
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 254
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 125
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 73
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 70
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 155
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 83
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 37
LMNA P02545 lamin A/C 1.00 0.384 0.885 425
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 186
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 86
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 141
COX8A P10176 cytochrome c oxidase subunit 8A Enzyme 0.12 0.400 0.846 37
SOX2 P48431 SRY-box transcription factor 2 Transcription factor 0.71 0.405 0.808 73
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 154
CASR P41180 calcium sensing receptor G-protein coupled receptor 4.7E-02 0.410 0.846 78
ELN P15502 elastin 2.1E-14 0.415 0.885 248
WNK1 Q9H4A3 WNK lysine deficient protein kinase 1 Kinase 1.00 0.416 0.846 40
SOX9 P48436 SRY-box transcription factor 9 1.00 0.419 0.846 119
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 210
DMD P11532 dystrophin 1.00 0.423 0.923 86