Source: CLINVAR

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
FZD4 Q9ULV1 frizzled class receptor 4 G-protein coupled receptor 0.97 0.490 0.923 12 8
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 11 25
ARSA P15289 arylsulfatase A Enzyme 1.1E-11 0.448 0.923 11 104
FLNB O75369 filamin B 6.1E-10 0.458 0.923 10 40
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923 9 26
SERPINA1 P01009 serpin family A member 1 Enzyme modulator 6.8E-08 0.410 0.923 9 45
PRNP F7VJQ1 P04156 prion protein 6.3E-04 0.445 0.923 8 24
INS P01308 insulin 0.30 0.445 0.923 7 28
ATR Q13535 ATR serine/threonine kinase Kinase 3.5E-09 0.456 0.923 6 9
BCHE P06276 butyrylcholinesterase 1.1E-13 0.447 0.923 6 26
SMAD3 P84022 SMAD family member 3 Transcription factor 0.80 0.415 0.923 6 32
MMP13 P45452 matrix metallopeptidase 13 Enzyme 7.9E-18 0.452 0.923 6 7
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 6 8
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 5 32
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 5 30
VCP P55072 valosin containing protein 1.00 0.469 0.923 5 15
GH1 P01241 growth hormone 1 Signaling 3.0E-02 0.373 0.923 4 13
NOD2 Q9HC29 nucleotide binding oligomerization domain containing 2 Enzyme 2.0E-30 0.423 0.923 4 15
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 3 1
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 3 5
PLG P00747 plasminogen Enzyme 1.0E-02 0.389 0.923 3 10
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 3 1
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 3 6
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 2 1