Source: CLINVAR

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 23 50
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 22 83
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 70 52
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 107 343
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 2 3
ALB P02768 albumin Transporter 0.64 0.317 0.962 6 9
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1 2
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 125 84
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 5 4
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 66 35
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 5 30
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 4 11
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 5 32
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 23 28
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 2 8
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 3 1
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 3 5
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 4 60
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 14 17
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 86 26
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 6 8
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 3 1
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 1 1
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 2 1