Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 167 4
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 138 40
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 138 5
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 130 54
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 115 30
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 110 65
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 109 3
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 109 1
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 101 18
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 98 61
PRL P01236 prolactin Signaling 2.9E-07 0.406 0.885 97 0
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 96 6