Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 1773 306
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 1640 21
IL6 P05231 interleukin 6 0.34 0.287 0.966 1330 16
VEGFA P15692 vascular endothelial growth factor A signaling molecule 2.7E-05 0.298 0.897 1174 32
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 1035 15
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 987 23
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 961 17
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 915 252
IFNG P01579 interferon gamma 0.47 0.323 0.897 901 6
EGFR P00533 epidermal growth factor receptor 0.50 0.325 0.862 892 88
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.38 0.321 0.828 891 108
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 886 38
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 871 92
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 847 25
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 835 60
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 832 24
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 790 19
APOE P02649 apolipoprotein E 1.7E-03 0.352 0.931 770 39
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 760 14
CXCL8 P10145 C-X-C motif chemokine ligand 8 signaling molecule 0.342 0.862 758 8
LMNA P02545 lamin A/C 1.00 0.406 0.724 727 213
HLA-DRB1 P01911 P01912 P04229 P13760 P13761 P20039 Q29974 Q30134 Q30167 Q5Y7A7 Q95IE3 Q9GIY3 Q9TQE0 major histocompatibility complex, class II, DR beta 1 defense/immunity protein 1.0E-03 0.347 0.897 719 26
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 715 24
STAT3 P40763 signal transducer and activator of transcription 3 nucleic acid binding; transcription factor 1.00 0.358 0.862 706 42