Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 151 0
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 138 40
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
LEP P41159 leptin 0.46 0.349 0.846 114 3
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 110 65
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 95 5
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 80 6
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 80 3
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 68 172
PPARA Q07869 peroxisome proliferator activated receptor alpha Nuclear receptor 3.0E-02 0.432 0.885 67 6
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 66 6
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 53 22
FN1 P02751 fibronectin 1 Signaling 1.4E-03 0.365 0.962 44 22
DNMT3A Q9Y6K1 DNA methyltransferase 3 alpha 7.4E-39 0.445 0.846 41 41
SLC11A1 P49279 solute carrier family 11 member 1 Transporter 1.5E-19 0.525 0.846 40 1
SMAD3 P84022 SMAD family member 3 Transcription factor 0.80 0.415 0.923 39 72
NR1H4 Q96RI1 nuclear receptor subfamily 1 group H member 4 Nuclear receptor 9.4E-04 0.513 0.808 39 3
IL12B P29460 interleukin 12B Signaling 1.1E-04 0.480 0.885 33 6
IL2RA P01589 interleukin 2 receptor subunit alpha Receptor 5.5E-02 0.389 0.885 31 30
TYK2 P29597 tyrosine kinase 2 Kinase 4.5E-08 0.505 0.769 31 15