Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 1228 107
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
LMNA P02545 lamin A/C 1.00 0.384 0.885 824 285
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 816 64
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 698 29
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 654 55
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 622 47
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 611 17
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 607 162
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 604 19
COL2A1 P02458 collagen type II alpha 1 chain 1.00 0.444 0.846 496 96
RAF1 P04049 Raf-1 proto-oncogene, serine/threonine kinase Kinase 0.85 0.418 0.885 470 52
SOX9 P48436 SRY-box transcription factor 9 1.00 0.419 0.846 466 25
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808 438 123
CHD7 Q9P2D1 chromodomain helicase DNA binding protein 7 1.00 0.441 0.846 419 247
TBX1 O43435 T-box transcription factor 1 Transcription factor 0.84 0.433 0.808 417 14
HSPG2 P98160 heparan sulfate proteoglycan 2 Enzyme modulator 1.0E-19 0.438 0.885 405 11
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 384 30
FLNB O75369 filamin B 6.1E-10 0.458 0.923 374 51
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 345 48
RYR1 P21817 ryanodine receptor 1 Ion channel 1.6E-29 0.489 0.808 320 248
GBA P04062 glucosylceramidase beta 1.4E-06 0.500 0.808 319 157
ERBB3 P21860 erb-b2 receptor tyrosine kinase 3 Kinase 1.7E-15 0.448 0.808 318 16
ABCC8 Q09428 ATP binding cassette subfamily C member 8 Transporter 8.0E-24 0.474 0.846 317 213