Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2475 28
IL6 P05231 interleukin 6 0.32 0.248 0.962 2132 21
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1737 58
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1604 22
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1533 21
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1334 32
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1308 143
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1277 41
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1160 28
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1105 16
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885 1087 12
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1077 12
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1050 26
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1043 27
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 1034 19
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1030 52
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1011 29
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 999 26
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 994 8
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 990 7
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 983 56
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 972 97
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 935 11
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 932 19