Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
RYR1 P21817 ryanodine receptor 1 Ion channel 1.6E-29 0.489 0.808 173
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808 117
SCN4A P35499 sodium voltage-gated channel alpha subunit 4 Ion channel 1.3E-02 0.554 0.731 112
CYP11B1 P15538 cytochrome P450 family 11 subfamily B member 1 8.2E-07 0.563 0.615 69
CACNA1S Q13698 calcium voltage-gated channel subunit alpha1 S Ion channel 6.3E-12 0.595 0.692 68
HSD3B2 P26439 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Enzyme 7.2E-08 0.582 0.500 57
CYP11A1 P05108 cytochrome P450 family 11 subfamily A member 1 5.5E-07 0.547 0.731 48
SCNN1B P51168 sodium channel epithelial 1 subunit beta Ion channel 5.8E-08 0.628 0.577 48
KCNJ18 B7U540 potassium inwardly rectifying channel subfamily J member 18 0.722 0.346 45
SCNN1A P37088 sodium channel epithelial 1 subunit alpha Ion channel 1.1E-11 0.601 0.577 45
SCNN1G P51170 sodium channel epithelial 1 subunit gamma Ion channel 0.48 0.633 0.577 45
TXNRD2 Q9NNW7 thioredoxin reductase 2 Enzyme 3.5E-11 0.548 0.731 44
MC2R Q01718 melanocortin 2 receptor G-protein coupled receptor 3.1E-04 0.582 0.654 40
WNK1 Q9H4A3 WNK lysine deficient protein kinase 1 Kinase 1.00 0.416 0.846 40
SAMD9 Q5K651 sterile alpha motif domain containing 9 1.1E-33 0.606 0.808 38
CYP11B2 P19099 cytochrome P450 family 11 subfamily B member 2 7.1E-19 0.553 0.615 37
GABRA3 P34903 gamma-aminobutyric acid type A receptor subunit alpha3 Ion channel 3.9E-02 0.636 0.577 37
MRAP Q8TCY5 melanocortin 2 receptor accessory protein 2.1E-03 0.674 0.500 36
STAR P49675 steroidogenic acute regulatory protein 8.8E-11 0.513 0.808 36
NNT Q13423 nicotinamide nucleotide transhydrogenase Enzyme 0.97 0.601 0.577 35
INVS Q9Y283 inversin 5.6E-18 0.619 0.538 29
ABCB6 Q9NP58 ATP binding cassette subfamily B member 6 (Langereis blood group) Transporter 8.6E-19 0.431 0.885 23
SLC30A9 Q6PML9 solute carrier family 30 member 9 Transporter 4.7E-07 0.736 0.385 18
NR3C2 P08235 nuclear receptor subfamily 3 group C member 2 Nuclear receptor 0.84 0.469 0.846 17