Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
IL6 P05231 interleukin 6 0.32 0.248 0.962 2367 22
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1801 22
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1558 50
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 1483 15
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1250 33
ALB P02768 albumin Transporter 0.64 0.317 0.962 1198 21
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 1193 57
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 1110 39
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 1028 7
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 1002 19
IL2 P60568 interleukin 2 0.48 0.336 0.885 950 5
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 933 59
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 852 81
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 816 119
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 684 974
MPO P05164 myeloperoxidase Enzyme 7.1E-15 0.377 0.923 653 25
EPO P01588 erythropoietin 1.1E-02 0.381 0.885 646 11
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 644 54
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 611 17
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 535 65
AHR P35869 aryl hydrocarbon receptor Transcription factor 1.00 0.410 0.923 532 20