Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
IFNG P01579 interferon gamma 0.47 0.288 0.962 91
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 77
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 72
FASLG P48023 Fas ligand Signaling 0.18 0.430 0.885 66
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 66
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 65
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 64
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 61
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 60
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 58
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 55
TNFSF10 P50591 TNF superfamily member 10 Signaling 0.13 0.413 0.885 54