Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 86
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 76
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 72
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 71
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 61
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 61
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 60
CDKN1A P38936 cyclin dependent kinase inhibitor 1A 1.9E-03 0.403 0.769 59
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 59
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 58
CXCL12 P48061 C-X-C motif chemokine ligand 12 0.12 0.379 0.846 53
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 53
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769 52
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 51