Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1899 59
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 1483 15
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 1254 10
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 1193 57
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1119 24
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885 1101 12
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1083 13
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 1018 185
IL2 P60568 interleukin 2 0.48 0.336 0.885 950 5
LMNA P02545 lamin A/C 1.00 0.384 0.885 824 285
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 823 34
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 816 64
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 774 33
CTLA4 P16410 cytotoxic T-lymphocyte associated protein 4 0.94 0.369 0.923 722 24
HLA-B P01889 major histocompatibility complex, class I, B 3.9E-05 0.379 0.885 706 308
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 706 39
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 703 97
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846 702 30
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 689 68
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 675 21
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 671 22