Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 63 218
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 54 50
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 52 72
HRAS P01112 HRas proto-oncogene, GTPase enzyme modulator 8.7E-02 0.404 0.828 40 20
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 37 33
NRAS P01111 NRAS proto-oncogene, GTPase enzyme modulator 0.53 0.420 0.690 36 14
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 32 230
CTNNB1 P35222 catenin beta 1 1.00 0.417 0.759 29 32
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus enzyme modulator 0.71 0.443 0.793 29 21
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 23 4
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 1.8E-03 0.352 0.862 22 26
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.38 0.321 0.828 21 60
KIT P10721 KIT proto-oncogene receptor tyrosine kinase 0.99 0.394 0.759 18 53
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1, cytosolic 3.3E-12 0.463 0.690 18 2
FBXW7 Q969H0 F-box and WD repeat domain containing 7 enzyme modulator 1.00 0.511 0.759 17 7
CREBBP Q92793 CREB binding protein nucleic acid binding; transcription factor; transferase 1.00 0.451 0.862 16 82
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 0.91 0.459 0.759 15 29
RAF1 P04049 Raf-1 proto-oncogene, serine/threonine kinase 0.89 0.462 0.793 13 25
MTOR P42345 mechanistic target of rapamycin kinase kinase; nucleic acid binding; transferase 1.00 0.399 0.793 13 17
B2M P61769 beta-2-microglobulin defense/immunity protein 0.48 0.499 0.759 12 6
PIK3R1 P27986 phosphoinositide-3-kinase regulatory subunit 1 enzyme modulator 1.00 0.515 0.793 11 20
SF3B1 O75533 splicing factor 3b subunit 1 nucleic acid binding 1.00 0.526 0.552 9 9
SF3B2 Q13435 splicing factor 3b subunit 2 1.00 0.799 0.276 9 2
MAP2K2 P36507 mitogen-activated protein kinase kinase 2 0.97 0.559 0.586 7 14