Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1314 146
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1234 27
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 1228 107
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 995 85
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 824 13
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 816 119
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 794 14
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 783 28
HLA-B P01889 major histocompatibility complex, class I, B 3.9E-05 0.379 0.885 706 308
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 703 97
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 698 29
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 689 68
HLA-A P04439 major histocompatibility complex, class I, A 1.3E-03 0.370 0.846 672 82
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 656 3066
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 635 7
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 610 18
PCNA P12004 proliferating cell nuclear antigen Nucleic acid binding 0.98 0.382 0.846 581 6
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 521 38
RAF1 P04049 Raf-1 proto-oncogene, serine/threonine kinase Kinase 0.85 0.418 0.885 470 52
PDGFRA P16234 platelet derived growth factor receptor alpha Kinase 1.00 0.415 0.808 452 44
TNFSF10 P50591 TNF superfamily member 10 Signaling 0.13 0.413 0.885 445 10