Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1558 50
GJB2 P29033 gap junction protein beta 2 Cell-cell junction 6.6E-16 0.441 0.846 392 132
BCHE P06276 butyrylcholinesterase 1.1E-13 0.447 0.923 392 101
NKX2-1 P43699 NK2 homeobox 1 Transcription factor 0.36 0.457 0.808 319 20
TPO P07202 thyroid peroxidase Enzyme 1.8E-21 0.455 0.846 306 47
PAX8 Q06710 paired box 8 1.00 0.477 0.731 253 24
TSHR P16473 thyroid stimulating hormone receptor G-protein coupled receptor 3.0E-15 0.486 0.808 250 77
TG P01266 thyroglobulin Enzyme modulator 2.9E-59 0.480 0.808 240 43
PPP1R2C O14990 PPP1R2C family member C Enzyme modulator 0.478 0.846 231 0
TBC1D24 Q9ULP9 TBC1 domain family member 24 Enzyme modulator 1.3E-08 0.530 0.808 218 39
SLC26A2 P50443 solute carrier family 26 member 2 Transporter 7.5E-07 0.553 0.692 198 78
SLC5A5 Q92911 solute carrier family 5 member 5 Transporter 2.9E-03 0.499 0.769 195 8
PTGDS P41222 prostaglandin D2 synthase Enzyme 5.1E-03 0.503 0.846 195 0
SLC26A4 O43511 solute carrier family 26 member 4 Transporter 9.0E-22 0.507 0.885 194 174
DUOX2 Q9NRD8 dual oxidase 2 Enzyme 4.5E-56 0.533 0.769 150 29
THRB P10828 thyroid hormone receptor beta Nuclear receptor 1.00 0.554 0.769 142 87
ALDH7A1 P49419 aldehyde dehydrogenase 7 family member A1 Enzyme 1.4E-22 0.551 0.769 141 34
SLC26A3 P40879 solute carrier family 26 member 3 Transporter 1.4E-13 0.554 0.692 128 58
HSPA8 P11142 heat shock protein family A (Hsp70) member 8 1.00 0.553 0.808 124 5
SLC13A5 Q86YT5 solute carrier family 13 member 5 Transporter 5.1E-04 0.608 0.577 106 14
F11 P03951 coagulation factor XI Enzyme 3.6E-26 0.590 0.692 100 139
DUOX1 Q9NRD9 dual oxidase 1 Enzyme 6.2E-33 0.570 0.692 97 1
KCNJ10 P78508 potassium inwardly rectifying channel subfamily J member 10 Ion channel 0.15 0.599 0.654 95 27
SLC5A8 Q8N695 solute carrier family 5 member 8 Transporter 5.0E-16 0.615 0.577 62 1