Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
IL6 P05231 interleukin 6 0.32 0.248 0.962 2367 22
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1899 59
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1801 22
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1679 21
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1558 50
IFNG P01579 interferon gamma 0.47 0.288 0.962 1519 11
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 1483 15
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1234 27
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
ALB P02768 albumin Transporter 0.64 0.317 0.962 1198 21
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1174 54
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 1110 39
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 1044 15
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 1021 43
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137
LMNA P02545 lamin A/C 1.00 0.384 0.885 824 285
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 819 26
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 816 119
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 783 28
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 774 33
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 765 43