Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 28
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 16
RAD21 O60216 RAD21 cohesin complex component 1.00 0.528 0.846 8
CCND2 P30279 cyclin D2 Enzyme modulator 0.99 0.477 0.808 4
ERCC1 P07992 ERCC excision repair 1, endonuclease non-catalytic subunit Enzyme 1.6E-07 0.445 0.846 3
RICTOR Q6R327 RPTOR independent companion of MTOR complex 2 1.00 0.592 0.615 3
RIT1 Q92963 Ras like without CAAX 1 Enzyme modulator 0.13 0.527 0.808 3
SLC22A18 Q96BI1 solute carrier family 22 member 18 Transporter 6.5E-06 0.595 0.692 3