Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 854 163
LMNA P02545 lamin A/C 1.00 0.384 0.885 824 285
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 805 74
FN1 P02751 fibronectin 1 Signaling 1.4E-03 0.365 0.962 724 33
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 664 387
MME P08473 membrane metalloendopeptidase Enzyme 1.5E-18 0.407 0.808 470 23
WNK1 Q9H4A3 WNK lysine deficient protein kinase 1 Kinase 1.00 0.416 0.846 460 26
HSPB1 P04792 heat shock protein family B (small) member 1 2.8E-07 0.436 0.808 395 31
TTN Q8WZ42 titin Kinase 2.6E-96 0.470 0.885 366 651
ATP7A Q04656 ATPase copper transporting alpha Transporter 1.00 0.494 0.769 348 107
PMP22 Q01453 peripheral myelin protein 22 Cellular structure 0.91 0.471 0.885 341 33
MFN2 O95140 mitofusin 2 Enzyme 0.99 0.471 0.846 334 75
HSPB3 Q12988 heat shock protein family B (small) member 3 6.1E-05 0.448 0.769 327 3
RYR1 P21817 ryanodine receptor 1 Ion channel 1.6E-29 0.489 0.808 320 248
SMN1 Q16637 survival of motor neuron 1, telomeric Epigenetic regulator 1.6E-02 0.454 0.769 317 30
LRP5 O75197 LDL receptor related protein 5 0.51 0.485 0.846 283 99
DNM1L O00429 dynamin 1 like Enzyme modulator 5.7E-04 0.475 0.808 273 15
MYH7 P12883 myosin heavy chain 7 4.2E-16 0.516 0.692 257 311
MPZ P25189 myelin protein zero 0.27 0.503 0.846 249 88
NEFL P07196 neurofilament light 0.488 0.769 247 26
STIM1 Q13586 stromal interaction molecule 1 0.78 0.501 0.808 247 23
FZD4 Q9ULV1 frizzled class receptor 4 G-protein coupled receptor 0.97 0.490 0.923 239 28
SYNE1 Q8NF91 spectrin repeat containing nuclear envelope protein 1 3.2E-52 0.511 0.846 237 76
LRRK2 Q5S007 leucine rich repeat kinase 2 Kinase 2.6E-30 0.510 0.808 231 74