Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Accordingly we hypothesized that ACTH-induced hypertension would be reversed by BH4 supplementation. 15132301

2004

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Accordingly we hypothesized that ACTH-induced hypertension would be reversed by BH4 supplementation. 15132301

2004

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human ACTH hypertension in the rat: role of kidney and gonads. 1664305

1991

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human ACTH hypertension in the rat: role of kidney and gonads. 1664305

1991

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human ACTH hypertension in the rat: role of sodium chloride. 1321011

1992

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human ACTH hypertension in the rat: role of sodium chloride. 1321011

1992

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human ACTH therapy in infantile spasms: side effects. 6254450

1980

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human ACTH therapy in infantile spasms: side effects. 6254450

1980

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Acute glucocorticoid (corticosterone) hypertension in the rate is significantly attenuated by neomycin administration (Honour 1981), as is ACTH-induced hypertension is the same species (Honour & Kent 1981) presumably by altering gut bacterial steroid metabolism. 6097376

1985

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Acute glucocorticoid (corticosterone) hypertension in the rate is significantly attenuated by neomycin administration (Honour 1981), as is ACTH-induced hypertension is the same species (Honour & Kent 1981) presumably by altering gut bacterial steroid metabolism. 6097376

1985

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Adrenocorticotrophic hormone-induced hypertension in the rat: effects of the endothelin antagonist bosentan. 10474778

1999

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Adrenocorticotrophic hormone-induced hypertension in the rat: effects of the endothelin antagonist bosentan. 10474778

1999

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Adrenocorticotrophin-induced hypertension in rats. Role of progesterone and digoxin-like substances. 8136112

1994

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Adrenocorticotrophin-induced hypertension in rats. Role of progesterone and digoxin-like substances. 8136112

1994

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Adrenocorticotrophin-induced hypertension in the rat: haemodynamic, metabolic and morphological characteristics. 2157753

1990

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Adrenocorticotrophin-induced hypertension in the rat: haemodynamic, metabolic and morphological characteristics. 2157753

1990

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Adrenocorticotrophin-induced hypertension: effects of mineralocorticoid and glucocorticoid receptor antagonism. 10100081

1999

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Adrenocorticotrophin-induced hypertension: effects of mineralocorticoid and glucocorticoid receptor antagonism. 10100081

1999

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human After 25 days (range 13 to 46) of treatment with ACTH, systolic blood pressure increased from 93 +/- 9 to 118 +/- 20 mm Hg (p < 0.001; mean +/- 1 SD). 8279378

1994

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human After 25 days (range 13 to 46) of treatment with ACTH, systolic blood pressure increased from 93 +/- 9 to 118 +/- 20 mm Hg (p < 0.001; mean +/- 1 SD). 8279378

1994

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Alterations in osmotic but not pressor responses to ACTH by optic recess lesions in sheep. 6279500

1982

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Alterations in osmotic but not pressor responses to ACTH by optic recess lesions in sheep. 6279500

1982

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats. 17994356

2007

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats. 17994356

2007

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Apocynin (but not allopurinol) co-treatment prevented (142+/-3 ACTH, 120+/-4 mm Hg apocynin+ACTH, P'<0.001) and reversed ACTH-induced hypertension (133+/-4 to 118+/-5 mm Hg, P<.05). 16053986

2005