Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Apocynin (but not allopurinol) co-treatment prevented (142+/-3 ACTH, 120+/-4 mm Hg apocynin+ACTH, P'<0.001) and reversed ACTH-induced hypertension (133+/-4 to 118+/-5 mm Hg, P<.05). 16053986

2005
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Arachidonic acid metabolism in glucocorticoid-induced hypertension. 18067589

2008
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Arachidonic acid metabolism in glucocorticoid-induced hypertension. 18067589

2008
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Atorvastatin prevented and partially reversed adrenocorticotropic hormone-induced hypertension in the rat. 16620303

2006
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Atorvastatin prevented and partially reversed adrenocorticotropic hormone-induced hypertension in the rat. 16620303

2006
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Based on the various biological effects of ACTH different explanations are proposed: oedema or deposition of glycogen in the myocardial tissue, hyperinsulinism, arterial hypertension and increased inotropic stimulus. 6088243

1984
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Based on the various biological effects of ACTH different explanations are proposed: oedema or deposition of glycogen in the myocardial tissue, hyperinsulinism, arterial hypertension and increased inotropic stimulus. 6088243

1984
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Besides via sympathetic inhibition, clonidine also may reduce the increased blood pressure further by normalizing central beta-endorphin release. 2455169

1987
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Besides via sympathetic inhibition, clonidine also may reduce the increased blood pressure further by normalizing central beta-endorphin release. 2455169

1987
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Beta-endorphin contributes to the antihypertensive effect of clonidine in a subset of patients with essential hypertension. 6089027

1984
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Beta-endorphin contributes to the antihypertensive effect of clonidine in a subset of patients with essential hypertension. 6089027

1984
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Changes in pressor responsiveness do not explain ACTH hypertension. 3015460

1986
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Changes in pressor responsiveness do not explain ACTH hypertension. 3015460

1986
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Children who develop hypertension during ACTH therapy should be considered at risk for hypertrophic cardiomyopathy and should undergo routine echocardiographic evaluation. 2821097

1987
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Children who develop hypertension during ACTH therapy should be considered at risk for hypertrophic cardiomyopathy and should undergo routine echocardiographic evaluation. 2821097

1987
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Circadian blood pressure variability in adrenocorticotrophin-induced hypertension in the rat. 11518849

2001
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Circadian blood pressure variability in adrenocorticotrophin-induced hypertension in the rat. 11518849

2001
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Corticotropin effects on blood pressure and fluid and electrolyte homeostasis in five strains of rats. 1316127

1992
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Corticotropin effects on blood pressure and fluid and electrolyte homeostasis in five strains of rats. 1316127

1992
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Cushing's disease in dogs and humans. 19153526

2009
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Cushing's disease in dogs and humans. 19153526

2009
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Cushing's syndrome secondary to ACTH-secreting Wilms' tumor. 4367732

1974
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Cushing's syndrome secondary to ACTH-secreting Wilms' tumor. 4367732

1974
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Dehydroepiandrosterone does not prevent adrenocorticotrophin-induced hypertension in conscious rats. 8713685

1996
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Dehydroepiandrosterone does not prevent adrenocorticotrophin-induced hypertension in conscious rats. 8713685

1996