×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms.
23827522
2013
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease.
16492752
2006
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.
28448946
2017
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study.
20640797
2010
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
12192006
2002
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
15590663
2005
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of beta-amyloid toxicity.
20111991
2010
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
30320580
2018
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.
20157255
2010
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
1671712
1991
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
High performance plasma amyloid-β biomarkers for Alzheimer's disease.
29420472
2018
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer's disease.
16266835
2006
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease.
19818510
2009
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease.
16325427
2006
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
16204253
2005
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease.
21157020
2011
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.
18583042
2008
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.
12572668
2003
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
16969627
2007
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
1678058
1991
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
APP/PS1 transgenic mice treated with aluminum: an update of Alzheimer's disease model.
22507317
2012
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
17239395
2007
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.
27117003
2016
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.
19286555
2009
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
15993441
2005