×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
1671712 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
1678058 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Vitamin E protects nerve cells from amyloid beta protein toxicity.
1497677 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
12192006 2002
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.
12572668 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease.
12746438 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation.
12852432 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
15590663 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
16204253 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
15993441 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.
15591071 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease.
16492752 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer's disease.
16266835 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease.
16325427 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.
16651627 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
16969627 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
17239395 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
"How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the ""LEARn"" model (latent early-life associated regulation) may explain the triggering of AD."
17430250 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.
18583042 2008
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease.
19818510 2009
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.
19286555 2009
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study.
20640797 2010
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of beta-amyloid toxicity.
20111991 2010
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.
20157255 2010
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease, Focal Onset
0.300
Biomarker
CTD_human
Aβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's disease.
21209907 2010