Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7827
Gene Symbol: NPHS2
NPHS2
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.700 Biomarker MGD

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.510 Biomarker RGD The serum alpha 2M concentration was increased approximately equal to 50-fold and was proportional to synthesis (r = 0.91 P < 0.001). alpha 2-Macroglobulin synthesis increased by 12-fold in NAR and 50-fold in NS. 9453001

1998
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.500 Biomarker RGD Abnormalities of coagulation in experimental nephrotic syndrome. 7532794

1994
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.400 Biomarker MGD

Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.340 Biomarker RGD Eight genes involved in cholesterol metabolism, Apo A-I, Acly, Acat, Mpd, Fdps, Ss, Lss, and Nsdhl, were significantly upregulated under NS. 18614621

2008
Entrez Id: 396
Gene Symbol: ARHGDIA
ARHGDIA
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.330 Biomarker MGD

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.300 Biomarker RGD Angiotensin I-converting enzyme activity in puromycin aminonucleoside-nephrotic syndrome. 2175683

1990
Entrez Id: 1514
Gene Symbol: CTSL
CTSL
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.220 Biomarker RGD Here, we show that the induction of puromycin aminonucleoside nephrosis involves podocyte migration conducted by a coordinated interplay between the cysteine protease cathepsin L and alpha(3) integrin. 15197181

2004
Entrez Id: 338
Gene Symbol: APOB
APOB
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.220 Biomarker RGD Hypoalbuminemia and proteinuria contribute separately to reduced lipoprotein catabolism in the nephrotic syndrome. 11135070

2001
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.220 Biomarker RGD Protective effects of Huang Qi Huai granules on adriamycin nephrosis in rats. 21359962

2011
Entrez Id: 4358
Gene Symbol: MPV17
MPV17
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.220 Biomarker MGD

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.220 Biomarker RGD Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat. 19194550

2009
Entrez Id: 2195
Gene Symbol: FAT1
FAT1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.210 Biomarker MGD

Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.210 Biomarker RGD The expression of prepro ET-1, ET-converting enzyme 1 (ECE-1), and ET A receptor mRNAs, but not ET B receptor mRNA, in the glomeruli was increased in rats with nephrotic syndrome. 12972712

2003
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.210 Biomarker RGD Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat. 19194550

2009
Entrez Id: 50618
Gene Symbol: ITSN2
ITSN2
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.210 Biomarker MGD

Entrez Id: 1889
Gene Symbol: ECE1
ECE1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD The expression of prepro ET-1, ET-converting enzyme 1 (ECE-1), and ET A receptor mRNAs, but not ET B receptor mRNA, in the glomeruli was increased in rats with nephrotic syndrome. 12972712

2003
Entrez Id: 8435
Gene Symbol: SOAT2
SOAT2
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome. 11967026

2002
Entrez Id: 57678
Gene Symbol: GPAM
GPAM
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. 18614621

2008
Entrez Id: 3758
Gene Symbol: KCNJ1
KCNJ1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD Inhibition of K+ secretion in the distal nephron in nephrotic syndrome: possible role of albuminuria. 21606114

2011
Entrez Id: 7436
Gene Symbol: VLDLR
VLDLR
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD The NS group showed a significant decline in VLDL-R protein (relative to total plasma membrane protein mass) in the heart and skeletal muscle paralleling the rise in plasma VLDL and triglyceride concentrations. 9186864

1997
Entrez Id: 4086
Gene Symbol: SMAD1
SMAD1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD Chinese herbal formula Qilong-Lishui granule improves puromycin aminonucleoside-induced renal injury through regulation of bone morphogenetic proteins. 17803470

2007
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker CTD_mouse Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats. 1281619

1992
Entrez Id: 6337
Gene Symbol: SCNN1A
SCNN1A
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats. 15075188

2004
Entrez Id: 1644
Gene Symbol: DDC
DDC
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD Blunted renal dopaminergic system activity in puromycin aminonucleoside-induced nephrotic syndrome. 16204272

2006