Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7827
Gene Symbol: NPHS2
NPHS2
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.700 Therapeutic RGD Proteinuria and glomerular nephrin and podocin immunofluorescence were examined in rat kidneys with adriamycin-induced NS and the effects of antiproteinuric drug therapies during 5 wk with enalapril, losartan, alone or in combination, omapatrilat, and mycophenolate mofetil on these parameters were assessed. 15942045

2005
Entrez Id: 7827
Gene Symbol: NPHS2
NPHS2
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.700 Biomarker MGD

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.510 Biomarker RGD The serum alpha 2M concentration was increased approximately equal to 50-fold and was proportional to synthesis (r = 0.91 P < 0.001). alpha 2-Macroglobulin synthesis increased by 12-fold in NAR and 50-fold in NS. 9453001

1998
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.500 Biomarker RGD Abnormalities of coagulation in experimental nephrotic syndrome. 7532794

1994
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.400 Therapeutic RGD Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of antiproteinuric therapies. 15942045

2005
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.400 Biomarker MGD

Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.340 Biomarker RGD Eight genes involved in cholesterol metabolism, Apo A-I, Acly, Acat, Mpd, Fdps, Ss, Lss, and Nsdhl, were significantly upregulated under NS. 18614621

2008
Entrez Id: 396
Gene Symbol: ARHGDIA
ARHGDIA
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.330 Biomarker MGD

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.300 Therapeutic RGD Nephrin loss is an indication of proteinuria in NS and the antiproteinuric effects of ACE inhibitors, vasopeptidase inhibitors, and mycophenolate mofetil attenuate this reduction. 15942045

2005
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.300 Biomarker RGD Angiotensin I-converting enzyme activity in puromycin aminonucleoside-nephrotic syndrome. 2175683

1990
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.220 Biomarker RGD Protective effects of Huang Qi Huai granules on adriamycin nephrosis in rats. 21359962

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.220 Biomarker RGD Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat. 19194550

2009
Entrez Id: 1514
Gene Symbol: CTSL
CTSL
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.220 Biomarker RGD Here, we show that the induction of puromycin aminonucleoside nephrosis involves podocyte migration conducted by a coordinated interplay between the cysteine protease cathepsin L and alpha(3) integrin. 15197181

2004
Entrez Id: 338
Gene Symbol: APOB
APOB
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.220 Biomarker RGD Hypoalbuminemia and proteinuria contribute separately to reduced lipoprotein catabolism in the nephrotic syndrome. 11135070

2001
Entrez Id: 4358
Gene Symbol: MPV17
MPV17
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.220 Biomarker MGD

Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.210 Biomarker RGD Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat. 19194550

2009
Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.210 Biomarker RGD The expression of prepro ET-1, ET-converting enzyme 1 (ECE-1), and ET A receptor mRNAs, but not ET B receptor mRNA, in the glomeruli was increased in rats with nephrotic syndrome. 12972712

2003
Entrez Id: 2195
Gene Symbol: FAT1
FAT1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.210 Biomarker MGD

Entrez Id: 50618
Gene Symbol: ITSN2
ITSN2
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.210 Biomarker MGD

Entrez Id: 1072
Gene Symbol: CFL1
CFL1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Therapeutic RGD Cyclosporine A protects podocytes via stabilization of cofilin-1 expression in the unphosphorylated state. 24737737

2014
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Therapeutic RGD Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage. 24812565

2014
Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD Disorder of fatty acid metabolism in the kidney of PAN-induced nephrotic rats. 22874759

2012
Entrez Id: 3758
Gene Symbol: KCNJ1
KCNJ1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD Inhibition of K+ secretion in the distal nephron in nephrotic syndrome: possible role of albuminuria. 21606114

2011
Entrez Id: 38
Gene Symbol: ACAT1
ACAT1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD Sterol regulatory element-binding proteins, liver X receptor, ABCA1 transporter, CD36, scavenger receptors A1 and B1 in nephrotic kidney. 19147991

2009
Entrez Id: 57678
Gene Symbol: GPAM
GPAM
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker RGD Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. 18614621

2008