Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4886
Gene Symbol: NPY1R
NPY1R
CUI: C0043020
Disease: Wallerian Degeneration
Wallerian Degeneration
0.200 Biomarker RGD An immunohistochemical marker for Wallerian degeneration of fibers in the central and peripheral nervous system. 10320723

1999

Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
CUI: C0043020
Disease: Wallerian Degeneration
Wallerian Degeneration
0.200 Biomarker RGD In line with its differential lesion-associated expression pattern, exogenous TGF-beta2 suppressed spontaneous myelin phagocytosis by microglia/macrophages in a mouse ex vivo assay of CNS and PNS Wallerian degeneration. 14997937

2004

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0043020
Disease: Wallerian Degeneration
Wallerian Degeneration
0.200 Biomarker RGD Lesion-associated expression of transforming growth factor-beta-2 in the rat nervous system: evidence for down-regulating the phagocytic activity of microglia and macrophages. 14997937

2004

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0043020
Disease: Wallerian Degeneration
Wallerian Degeneration
0.200 Biomarker RGD Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. 9030624

1997

Entrez Id: 1910
Gene Symbol: EDNRB
EDNRB
CUI: C1848519
Disease: WAARDENBURG SYNDROME, TYPE 4A
WAARDENBURG SYNDROME, TYPE 4A
1.000 Biomarker RGD Genetic background strongly modifies the severity of symptoms of Hirschsprung disease, but not hearing loss in rats carrying Ednrb(sl) mutations. 21915282

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0042995
Disease: Vulvar Neoplasms
Vulvar Neoplasms
0.200 Biomarker RGD [Establishment of a rat model of dimethylbenzanthracene-induced vulvar squamous intraepithelial lesions]. 30514679

2018

Entrez Id: 6521
Gene Symbol: SLC4A1
SLC4A1
CUI: C0042875
Disease: Vitamin E Deficiency
Vitamin E Deficiency
0.200 Biomarker RGD Oxidation as a possible mechanism of cellular aging: vitamin E deficiency causes premature aging and IgG binding to erythrocytes. 3458208

1986

Entrez Id: 56729
Gene Symbol: RETN
RETN
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency
0.220 Biomarker RGD Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation. 21994008

2012

Entrez Id: 632
Gene Symbol: BGLAP
BGLAP
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency
0.210 Biomarker RGD The dichotomy in the effects of 1,25 dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 on bone gamma-carboxyglutamic acid-containing protein in serum and bone in vitamin D-deficient rats. 3105848

1987

Entrez Id: 189
Gene Symbol: AGXT
AGXT
CUI: C0042850
Disease: Vitamin B Deficiency
Vitamin B Deficiency
0.200 Biomarker RGD Hepatic alanine-glyoxylate aminotransferase activity and oxalate metabolism in vitamin B6 deficient rats. 12544342

2003

Entrez Id: 191
Gene Symbol: AHCY
AHCY
CUI: C0936215
Disease: Vitamin B 6 Deficiency
Vitamin B 6 Deficiency
0.200 Biomarker RGD Effect of vitamin B6 deficiency on the synthesis and accumulation of S-adenosylhomocysteine and S-adenosylmethionine in rat tissues. 11575573

2001

Entrez Id: 4548
Gene Symbol: MTR
MTR
CUI: C0042847
Disease: Vitamin B 12 Deficiency
Vitamin B 12 Deficiency
0.220 Biomarker RGD The aim of this study was to assess the respective influence of folate and vitamin B12 deficiency on MTR transcription and activity, and on DNA methylation. 14646334

2003

Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
CUI: C0042847
Disease: Vitamin B 12 Deficiency
Vitamin B 12 Deficiency
0.200 Therapeutic RGD Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy. 16716410

2006

Entrez Id: 811
Gene Symbol: CALR
CALR
CUI: C0042847
Disease: Vitamin B 12 Deficiency
Vitamin B 12 Deficiency
0.200 Biomarker RGD Maternal micronutrient deficiency leads to alteration in the kidney proteome in rat pups. 25982389

2015

Entrez Id: 1072
Gene Symbol: CFL1
CFL1
CUI: C0042847
Disease: Vitamin B 12 Deficiency
Vitamin B 12 Deficiency
0.200 Biomarker RGD Maternal micronutrient deficiency leads to alteration in the kidney proteome in rat pups. 25982389

2015

Entrez Id: 1592
Gene Symbol: CYP26A1
CYP26A1
CUI: C0042842
Disease: Vitamin A Deficiency
Vitamin A Deficiency
0.220 Biomarker RGD Vitamin A status affects obesity development and hepatic expression of key genes for fuel metabolism in Zucker fatty rats. 22554462

2012

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0042842
Disease: Vitamin A Deficiency
Vitamin A Deficiency
0.210 Biomarker RGD Vitamin A deficiency increased liver hepcidin mRNA and iron spleen concentrations; however, iron deficiency in vitamin A-deficient rats deeply inhibits liver hepcidin mRNA expression and significantly increases divalent metal transporter-1 mRNA levels. 19217259

2009

Entrez Id: 8694
Gene Symbol: DGAT1
DGAT1
CUI: C0042842
Disease: Vitamin A Deficiency
Vitamin A Deficiency
0.200 Biomarker RGD Alterations in the lipid metabolism of rat aorta: effects of vitamin a deficiency. 17047345

2006

Entrez Id: 7412
Gene Symbol: VCAM1
VCAM1
CUI: C0042842
Disease: Vitamin A Deficiency
Vitamin A Deficiency
0.200 Biomarker RGD Implication of vitamin A deficiency on vascular injury related to inflammation and oxidative stress. Effects on the ultrastructure of rat aorta. 21512820

2012

Entrez Id: 3658
Gene Symbol: IREB2
IREB2
CUI: C0042842
Disease: Vitamin A Deficiency
Vitamin A Deficiency
0.200 Biomarker RGD The IRP2 mRNA level of the rats in the test groups was approximately two times that of the control group, whereas the Fn mRNA level and the TfR mRNA level were downregulated and upregulated, respectively, by the vitamin A deficiency. 22154532

2012

Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0270824
Disease: Visual seizure
Visual seizure
0.500 Biomarker RGD Induction of DNA repair proteins, Ref-1 and XRCC1, in adult rat brain following kainic acid-induced seizures. 15854596

2005

Entrez Id: 4804
Gene Symbol: NGFR
NGFR
CUI: C0270824
Disease: Visual seizure
Visual seizure
0.500 Therapeutic RGD Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat. 12873743

2003

Entrez Id: 348980
Gene Symbol: HCN1
HCN1
CUI: C0270824
Disease: Visual seizure
Visual seizure
0.500 Biomarker RGD Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. 17988239

2008

Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0270824
Disease: Visual seizure
Visual seizure
0.500 Therapeutic RGD Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation. 20109543

2010

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0270824
Disease: Visual seizure
Visual seizure
0.500 Biomarker RGD Differential susceptibility of interneurons expressing neuropeptide Y or parvalbumin in the aged hippocampus to acute seizure activity. 21915341

2011