Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_human In contrast, the metastasis-derived COH tumor expressed very high levels of active MMP-9. 15659795

2004
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.540 Biomarker CTD_human Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells. 15725655

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker CTD_human Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells. 15725655

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0020507
Disease: Hyperplasia
Hyperplasia 		0.310 Biomarker CTD_human Increased matrix metalloproteinase-9 (MMP-9) expression is associated with intimal hyperplasia in saphenous vein (SV) bypass grafts. 15728660

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0243026
Disease: Sepsis
Sepsis 		0.540 Biomarker CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0036690
Disease: Septicemia
Septicemia 		0.330 Biomarker CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0034189
Disease: Pyemia
Pyemia 		0.300 Biomarker CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.300 Biomarker CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0162872
Disease: Aortic Aneurysm, Thoracic
Aortic Aneurysm, Thoracic 		0.510 Biomarker CTD_human Effects of deletion of the matrix metalloproteinase 9 gene on development of murine thoracic aortic aneurysms. 16159824

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0340630
Disease: Aortic Aneurysm, Thoracoabdominal
Aortic Aneurysm, Thoracoabdominal 		0.300 Biomarker CTD_human Effects of deletion of the matrix metalloproteinase 9 gene on development of murine thoracic aortic aneurysms. 16159824

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage 		0.300 Biomarker CTD_human Our findings suggest that endogenous tPA plays an important role in heparin-produced cerebral hemorrhage via MMP9 induction and activation. 16190367

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage 		0.300 Therapeutic CTD_human Our findings suggest that endogenous tPA plays an important role in heparin-produced cerebral hemorrhage via MMP9 induction and activation. 16190367

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker CTD_human Effects of carvedilol on cardiac cytokines expression and remodeling in rat with acute myocardial infarction. 16310260

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0029172
Disease: Oral Submucous Fibrosis
Oral Submucous Fibrosis 		0.330 Biomarker CTD_human Oral submucous fibrosis: review on aetiology and pathogenesis. 16311067

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_human Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases. 16475674

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0005967
Disease: Bone neoplasms
Bone neoplasms 		0.320 Biomarker CTD_human Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases. 16475674

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0279530
Disease: Malignant Bone Neoplasm
Malignant Bone Neoplasm 		0.300 Biomarker CTD_human Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases. 16475674

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker CTD_human Our results also show that treatment of U87MG cells with the two isoflavones induced decreases in the enzymatic activity of MMP-9 and the protein levels of MT1-MMP and uPAR. 16598420

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker CTD_human Our results also show that treatment of U87MG cells with the two isoflavones induced decreases in the enzymatic activity of MMP-9 and the protein levels of MT1-MMP and uPAR. 16598420

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0334588
Disease: Giant Cell Glioblastoma
Giant Cell Glioblastoma 		0.300 Biomarker CTD_human Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones. 16598420

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker CTD_human Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression. 16606632

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human We demonstrate that treatment of human prostate cancer cell lines with zinc reduces expression of VEGF, IL-6, IL-8 and MMP-9. 16606632

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0023176
Disease: Lead Poisoning
Lead Poisoning 		0.300 Biomarker CTD_human Matrix metalloproteinase-9 activity in plasma correlates with plasma and whole blood lead concentrations. 16700817

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.600 Biomarker CTD_human Experimental abdominal aortic aneurysm formation is associated with early increases in MnSOD expression and an increase in MMP-9 activity. 17196988

2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer 		0.500 Biomarker CTD_human We investigated the activity and expression of MMP-9 and -2 in ethanol-induced acute gastric ulceration in rats. 17603938

2007