Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker CTD_human MMP-9 protein levels were increased in the non-infarct region of WT-MI vs WT-sham. 24358288

2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_human Resveratrol modulates MED28 (Magicin/EG-1) expression and inhibits epidermal growth factor (EGF)-induced migration in MDA-MB-231 human breast cancer cells. 21942447

2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.600 Biomarker CTD_human In this study, we examined the sequential expression of MMP-2, MMP-9 and TIMP-1 in a rat model of pulmonary fibrosis induced by PQ. 21468558

2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human Fosinopril and valsartan intervention in gene expression of Klotho, MMP-9, TIMP-1, and PAI-1 in the kidney of spontaneously hypertensive rats. 21051829

2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_human Treatment of mice with resveratrol and TRAIL alone inhibited angiogenesis (as demonstrated by reduced number of blood vessels, and VEGF and VEGFR2 positive cells) and markers of metastasis (MMP-2 and MMP-9). 21209944

2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.600 Biomarker CTD_human However, it remained uncertain how cigarette smoke induced MMP-9 and how simvastatin inhibited cigarette smoke-induced MMP-9 expression in alveolar macrophages (AMs), a major source of MMP-9 in the lungs of COPD patients. 19299917

2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_human Altered redox status accompanies progression to metastatic human bladder cancer. 18930813

2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.600 Biomarker CTD_human Experimental abdominal aortic aneurysm formation is associated with early increases in MnSOD expression and an increase in MMP-9 activity. 17196988

2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker CTD_human Effects of carvedilol on cardiac cytokines expression and remodeling in rat with acute myocardial infarction. 16310260

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_human Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases. 16475674

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker CTD_human Previous studies have reported that MMP-9 might play a role in chronic airway inflammation and remodeling in asthma. 15131573

2004
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_human In contrast, the metastasis-derived COH tumor expressed very high levels of active MMP-9. 15659795

2004
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker CTD_human Murine TDI-induced asthma includes findings of (1) increased inflammatory cells, including neutrophils, lymphocytes, and eosinophils; (2) histologic changes, including infiltration of inflammatory cells around bronchioles, thickened airway epithelium, and accumulation of mucus and debris in the bronchioles; (3) increased MMP-9 activity in inflammatory cells in the airway lumen; and (4) airway hyperresponsiveness. 11742282

2001
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia 		0.560 Biomarker CTD_human Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia. 15060315

2004
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.540 Biomarker CTD_human Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells. 15725655

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0243026
Disease: Sepsis
Sepsis 		0.540 Biomarker CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Biomarker CTD_human Resveratrol mitigates rat retinal ischemic injury: the roles of matrix metalloproteinase-9, inducible nitric oxide, and heme oxygenase-1. 23075401

2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0162872
Disease: Aortic Aneurysm, Thoracic
Aortic Aneurysm, Thoracic 		0.510 Biomarker CTD_human Effects of deletion of the matrix metalloproteinase 9 gene on development of murine thoracic aortic aneurysms. 16159824

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment. 22191573

2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human Altered matrix metalloproteinases and tissue inhibitors of metalloproteinases in embryos from diabetic rats during early organogenesis. 21963884

2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.500 Biomarker CTD_human The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells. 21283680

2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.500 Biomarker CTD_human 5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9. 19309543

2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer 		0.500 Biomarker CTD_human We investigated the activity and expression of MMP-9 and -2 in ethanol-induced acute gastric ulceration in rats. 17603938

2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C2936380
Disease: Neointima
Neointima 		0.500 Biomarker CTD_human Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis. 17964422

2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0026766
Disease: Multiple Organ Failure
Multiple Organ Failure 		0.500 Biomarker CTD_human In conclusion, the data suggest a role for MMPs, especially MMP-9, in the pathogenesis of MODS. 15259001

2004