Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Reduced cell-cell communication in a spontaneous murine model of autoimmune thyroid disease. 7628400

1995
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. 6610701

1984
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Lymphocytic infiltration and goblet cell marker alteration in the conjunctiva of the MRL/MpJ-Fas(lpr) mouse model of Sjögren's syndrome. 17208228

2007
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Cognitive and neurologic deficits in the MRL/lpr mouse: a clinicopathologic study. 8496852

1993
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Induction of various autoantibodies by mutant gene lpr in several strains of mice. 6609979

1984
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene. 6975351

1981
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice. 17142777

2006
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 11067882

2000
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Lacrimal and salivary gland inflammation in the C3H/Ipr autoimmune strain mouse: a potential mode for Sjögren's syndrome. 1565490

1992
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Unexpected development of autoimmunity in BAFF-R-mutant MRL-lpr mice. 17073941

2007
Entrez Id: 3399
Gene Symbol: ID3
ID3
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.210 Biomarker MGD A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. 15485632

2004
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance. 16709807

2006
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation. 22590468

2012
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice. 17207605

2006
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. 12196288

2002
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice. 17207605

2006
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Sjögren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. 16413168

2006
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon. 15613333

2005
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD T-cell receptor repertoire of infiltrating T cells in lachrymal glands, salivary glands and kidneys from alymphoplasia (aly) mutant mice: a new model for Sjögren's syndrome. 9010048

1996
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. 14764671

2004
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Homeostatic regulation of intestinal villous epithelia by B lymphocytes. 11884426

2002
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Mammary glands of Aly mice: developmental changes and lactation-related expression of specific proteins, alpha-casein, GLyCAM-1 and MAdCAM-1. 10910194

2000
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. 12810685

2003
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Nematode infection in Alymphoplasia (aly) mice: worm species-dependent differential effect of defects of the gut-associated lymphatic tissue system. 16640660

2006
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Impaired function of dendritic cells in alymphoplasia (aly/aly) mice for expansion of CD25+CD4+ regulatory T cells. 17060023

2006