Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3312
Gene Symbol: HSPA8
HSPA8
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Irreversible aggregation of protein synthesis machinery after focal brain ischemia. 16805800

2006

Entrez Id: 2021
Gene Symbol: ENDOG
ENDOG
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia. 18568342

2008

Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons. 9030714

1997

Entrez Id: 7054
Gene Symbol: TH
TH
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Selective losses of brainstem catecholamine neurons after hypoxia-ischemia in the immature rat pup. 18356740

2008

Entrez Id: 2674
Gene Symbol: GFRA1
GFRA1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats. 10407114

1999

Entrez Id: 3313
Gene Symbol: HSPA9
HSPA9
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD In situ analysis of normal brain reveals an unusual distribution, with very high expression in neurons of the basal forebrain, reticular and subthalamic nuclei, globus pallidus, amygdala and elsewhere. grp75-mRNA is upregulated following focal brain ischemia in a distinctive fashion. 7629893

1995

Entrez Id: 5111
Gene Symbol: PCNA
PCNA
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Specific expression of the cell cycle regulation proteins, GADD34 and PCNA, in the peri-infarct zone after focal cerebral ischaemia in the rat. 12099899

2002

Entrez Id: 5599
Gene Symbol: MAPK8
MAPK8
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation. 15797868

2005

Entrez Id: 572
Gene Symbol: BAD
BAD
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14-3-3. 18078455

2008

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD The physiopathology of the brain ischemia includes many events such as important apoptotic mechanisms were Fas protein is expressed. 16796407

2006

Entrez Id: 2057
Gene Symbol: EPOR
EPOR
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Permanent focal cerebral ischemia activates erythropoietin receptor in the neonatal rat brain. 14732457

2004

Entrez Id: 1808
Gene Symbol: DPYSL2
DPYSL2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke. 19524114

2009

Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. 21925238

2011

Entrez Id: 4671
Gene Symbol: NAIP
NAIP
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus. 9288726

1997

Entrez Id: 4899
Gene Symbol: NRF1
NRF1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury. 18723421

2008

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Activation of Src tyrosine kinase in microglia in the rat hippocampus following transient forebrain ischemia. 15854740

2005

Entrez Id: 2246
Gene Symbol: FGF1
FGF1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Protective effects of mutant of acidic fibroblast growth factor against cerebral ischaemia-reperfusion injury in rats. 19497570

2009

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury. 16417587

2006

Entrez Id: 9590
Gene Symbol: AKAP12
AKAP12
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema. 21334414

2011

Entrez Id: 361
Gene Symbol: AQP4
AQP4
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. 19616516

2009

Entrez Id: 9510
Gene Symbol: ADAMTS1
ADAMTS1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD The quantification of ADAMTS expression in an animal model of cerebral ischemia using real-time PCR. 17073862

2007

Entrez Id: 343
Gene Symbol: AQP8
AQP8
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. 19616516

2009

Entrez Id: 9361
Gene Symbol: LONP1
LONP1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease. 12082077

2002

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Expression of heme oxygenase-1 protein and messenger RNA in permanent cerebral ischemia in rats. 16464361

2006

Entrez Id: 4440
Gene Symbol: MSI1
MSI1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia. 12205668

2002