×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of lung
0.800
Biomarker
CTD_human
Genomic landscape of cutaneous T cell lymphoma.
26192916 2015
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of lung
0.800
Therapeutic
CTD_human
Genomic landscape of cutaneous T cell lymphoma.
26192916 2015
×
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
Malignant neoplasm of lung
0.800
Biomarker
CTD_human
We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)).
24880342 2014
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of lung
0.800
Therapeutic
CTD_human
The present study reveals a detrimental role of nicotine especially in lung cancer patients with impaired p53 status and identifies curcumin as a potential chemopreventive.
20727180 2010
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of lung
0.800
Biomarker
CTD_human
The present study reveals a detrimental role of nicotine especially in lung cancer patients with impaired p53 status and identifies curcumin as a potential chemopreventive.
20727180 2010
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of lung
0.800
Therapeutic
CTD_human
Interestingly, XPC hypermethylation was found in 4 of 5 (80%) lung cancer cell lines harbored p53 mutation, but not observed in two lung cancer cells which had a wild-type p53 gene.
17325666 2007
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of lung
0.800
Biomarker
CTD_human
Interestingly, XPC hypermethylation was found in 4 of 5 (80%) lung cancer cell lines harbored p53 mutation, but not observed in two lung cancer cells which had a wild-type p53 gene.
17325666 2007
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of lung
0.800
Therapeutic
CTD_human
Genetic alterations in cancer knowledge system: analysis of gene mutations in mouse and human liver and lung tumors.
16410370 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of lung
0.800
Biomarker
CTD_human
Genetic alterations in cancer knowledge system: analysis of gene mutations in mouse and human liver and lung tumors.
16410370 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of lung
0.800
Therapeutic
CTD_human
[Experimental study on combination of Ad-p53 with CDDP or As(2)O(3) in human lung adenocarcinoma cell line GLC-82].
11798837 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of lung
0.800
Biomarker
CTD_human
[Experimental study on combination of Ad-p53 with CDDP or As(2)O(3) in human lung adenocarcinoma cell line GLC-82].
11798837 2000
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
Lung cancer cells expressing oncogenic K-Ras have bypassed the senescence barrier.29247004 2018
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling.
25851810 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
26390243 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I.
22028818 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
CRM1-dependent p53 nuclear accumulation in lung lesions of a bitransgenic mouse lung tumor model.
21519798 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
Human lung cancer patients exhibit different KRAS mutations depending on smoking status.
20101149 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
The Egfr and K-ras gene mutations were detected at sites also found in human lung cancers with low incidences, while the Egfr gene mutation was detected for the first time in chemical lung carcinogenesis of animals.
19336973 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
In this study, we demonstrate that K-Ras , a frequently altered oncogene in human cancers including pancreatic cancer (about 80%), colon cancer (45%) and lung cancer (45%), suppresses p53.
19424582 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaavia diffusa.
19555203 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.
18758463 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis.
18062963 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
Genetically engineered murine models of mutant EGFR and KRAS have been developed that more accurately recapitulate human lung cancer .
18927287 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
Lung cancer in never smokers: a review.
17290066 2007
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of lung
0.700
Biomarker
CTD_human
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
17233834 2007