Source: CURATED

Gene Gene Full Name DSI g DPI g pLI Disease Type Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 351
Gene Symbol: APP
APP 		amyloid beta precursor protein 0.422 0.846 4.7E-02
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 0.986 35 0 1991 2019
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		presenilin 1 0.469 0.846 0.97
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 0.938 13 0 1995 2020
Entrez Id: 348
Gene Symbol: APOE
APOE 		apolipoprotein E 0.338 0.962 1.9E-03
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 0.956 9 0 1993 2020
Entrez Id: 4137
Gene Symbol: MAPT
MAPT 		microtubule associated protein tau 0.446 0.923 6.0E-03
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 0.944 7 0 2003 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE 		angiotensin I converting enzyme 0.328 0.923 1.0E-37
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 1.000 5 0 1999 2019
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40 		translocase of outer mitochondrial membrane 40 0.590 0.538 0.99
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 0.917 4 0 2007 2018
Entrez Id: 1191
Gene Symbol: CLU
CLU 		clusterin 0.426 0.885 7.8E-05
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 1.000 3 0 2009 2019
Entrez Id: 8301
Gene Symbol: PICALM
PICALM 		phosphatidylinositol binding clathrin assembly protein 0.592 0.538 1.00
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 0.963 2 0 2009 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2 		triggering receptor expressed on myeloid cells 2 0.519 0.769 3.3E-09
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 0.938 2 0 2013 2019
Entrez Id: 945
Gene Symbol: CD33
CD33 		CD33 molecule 0.524 0.769 5.7E-07
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 1.000 2 0 2011 2019
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7 		ATP binding cassette subfamily A member 7 0.644 0.577 2.1E-55
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 1.000 2 0 2011 2020
Entrez Id: 274
Gene Symbol: BIN1
BIN1 		bridging integrator 1 0.550 0.692 0.78
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 1.000 1 0 2011 2020
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		methylenetetrahydrofolate reductase 0.337 0.885 3.2E-10
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 0.909 1 0 2001 2019
Entrez Id: 3416
Gene Symbol: IDE
IDE 		insulin degrading enzyme 0.604 0.577 6.6E-03
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 1.000 1 0 2001 2017
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		butyrylcholinesterase 0.447 0.923 1.1E-13
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.400 None 0.909 1 0 1998 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1 		beta-secretase 1 0.559 0.769 0.88
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.390 None 1.000 1 0 2001 2020
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		peroxisome proliferator activated receptor gamma 0.358 0.885 2.9E-02
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.380 None 0.909 3 0 2005 2018
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2 		presenilin 2 0.550 0.654 5.4E-04
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.380 None 1.000 3 0 1997 2019
Entrez Id: 2
Gene Symbol: A2M
A2M 		alpha-2-macroglobulin 0.529 0.769 4.5E-11
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.370 None 0.800 3 0 1998 2010
Entrez Id: 2041
Gene Symbol: EPHA1
EPHA1 		EPH receptor A1 0.544 0.731 1.5E-23
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.370 None 1.000 2 0 2011 2020
Entrez Id: 1471
Gene Symbol: CST3
CST3 		cystatin C 0.436 0.808 3.9E-03
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.370 None 0.778 2 0 2000 2009
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		brain derived neurotrophic factor 0.345 0.923 0.66
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.370 None 1.000 1 0 2001 2020
Entrez Id: 1378
Gene Symbol: CR1
CR1 		complement C3b/C4b receptor 1 (Knops blood group) 0.533 0.808 1.6E-35
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.350 None 1.000 2 0 2009 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		nitric oxide synthase 3 0.378 0.885 6.7E-07
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.350 None 1.000 2 0 1999 2010
Entrez Id: 27328
Gene Symbol: PCDH11X
PCDH11X 		protocadherin 11 X-linked 0.729 0.308 1.6E-02
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		disease 0.350 None 0.400 1 0 2009 2011